“Wooly mice” a test run for mammoth gene editing

With most targeted changes not mammoth-specific, the focus is on gene editing.

On Tuesday, the team behind the plan to bring mammoth-like animals back to the tundra announced the creation of what it is calling wooly mice, which have long fur reminiscent of the woolly mammoth. The long fur was created through the simultaneous editing of as many as seven genes, all with a known connection to hair growth, color, and/or texture.

But don't think that this is a sort of mouse-mammoth hybrid. Most of the genetic changes were first identified in mice, not mammoths. So, the focus is on the fact that the team could do simultaneous editing of multiple genes—something that they'll need to be able to do to get a considerable number of mammoth-like changes into the elephant genome.

Of mice and mammoths

The team at Colossal Biosciences has started a number of de-extinction projects, including the dodo and thylacine, but its flagship project is the mammoth. In all of these cases, the plan is to take stem cells from a closely related species that has not gone extinct, and edit a series of changes based on the corresponding genomes of the deceased species. In the case of the mammoth, that means the elephant.

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AOOSTAR WTR MAX is a 7-bay NAS with AMD Ryzen 8040HS

The AOOSTAR WTR MAX  is an upcoming network attached storage device with support for up to 6 hard drives and 6 SSDs, an AMD Ryzen 8040HS “Hawk Point” processor, support for up to 32GB of DDR5-5600 dual-channel memory, and four high-speed ne…

The AOOSTAR WTR MAX  is an upcoming network attached storage device with support for up to 6 hard drives and 6 SSDs, an AMD Ryzen 8040HS “Hawk Point” processor, support for up to 32GB of DDR5-5600 dual-channel memory, and four high-speed networking ports. In other words, it’s like the big sibling of the AOOSTAR WTR Pro, […]

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Cod liver oil embraced amid Texas measles outbreak; doctors fight misinfo

Overdoses of vitamin A have serious risks—and it doesn’t prevent measles.

US Health Secretary and long-standing anti-vaccine advocate Robert F. Kennedy Jr. is facing criticism for his equivocal response to the raging measles outbreak in West Texas, which as of Tuesday has grown to 159 cases, with 22 hospitalizations and one child death.

While public health officials would like to see a resounding endorsement of the Measles, Mumps, and Rubella (MMR) vaccine as the best way to protect children and vulnerable community members from further spread of the extremely infectious virus, Kennedy instead penned an Op-Ed for Fox News sprinkled with anti-vaccine talking points. Before noting that vaccines "protect individual children" and "contribute to community immunity," he stressed parental choice. The decision to vaccinate is "a personal one," he wrote, and merely advised parents to "consult with their healthcare providers to understand their options to get the MMR vaccine."

Further, Kennedy seemed more eager to embrace nutrition and supplements as a way to combat the potentially deadly infection. He declared that the "best defense" against infectious diseases, like the measles, is "good nutrition"—not lifesaving, highly effective vaccines.

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George Orwell’s 1984 as a ’90s PC game has to be seen to be believed

A “zero gravity training sphere” makes an appearance, obviously.

Most readers come away from George Orwell's classic dystopian novel 1984 with the same singular desire: to inhabit the world of the book by playing a late '90s first-person puzzle-adventure PC game that includes a "zero-g training sphere" for some reason. In 1998, publisher MediaX set out to satisfy that widespread literary desire with Big Brother, an officially licensed "sequel" game set in the 1984 universe.

After appearing as a demo at E3 1998 and receiving some scattered press coverage, the Big Brother project fell apart before the game could see a full release. Now, though, you can experience a small taste of this ill-fated literary sequel thanks to a newly unearthed demo that was recovered and posted to the Internet Archive over the weekend.

War is Peace

The Lost Media Wiki has a bit more info on the history of Big Brother, which was announced in May 1998 as the first game ever from multimedia CD-ROM maker MediaX. In that announcement, the company said the game would move focus away from 1984's Winston Smith and to new character Eric Blair, who's on a search for his missing fiancée Emma (sure, why not) in "a completely changed world dominated by the Thought Police."

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Threat posed by new VMware hyperjacking vulnerabilities is hard to overstate

Just one compromised VM can make all other VMs on that hypervisor sitting ducks.

Three critical vulnerabilities in multiple virtual-machine products from VMware can give hackers unusually broad access to some of the most sensitive environments inside multiple customers’ networks, the company and outside researchers warned Tuesday.

The class of attack made possible by exploiting the vulnerabilities is known under several names, including hyperjacking, hypervisor attack, or virtual machine escape. Virtual machines often run inside hosting environments to prevent one customer from being able to access or control the resources of other customers. By breaking out of one customer’s isolated VM environment, a threat actor could take control of the hypervisor that apportions each VM. From there, the attacker could access the VMs of multiple customers, who often use these carefully controlled environments to host their internal networks.

All bets off

“If you can escape to the hypervisor you can access every system,” security researcher Kevin Beaumont said on Mastodon. “If you can escape to the hypervisor, all bets are off as a boundary is broken.” He added: “With this vuln you’d be able to use it to traverse VMware managed hosting providers, private clouds orgs have built on prem etc.”

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Do these dual images say anything about your personality?

Personality quizzes based on ambiguous images are bunk, but we can still learn from such psychological myths.

There's little that Internet denizens love more than a snazzy personality test—cat videos, maybe, or perpetual outrage. One trend that has gained popularity over the last several years is personality quizzes based on so-called ambiguous images—in which one sees either a young girl or an old man, for instance, or a skull or a little girl. It's possible to perceive both images by shifting one's perspective, but it's the image one sees first that is said to indicate specific personality traits. According to one such quiz, seeing the young girl first means you are optimistic and a bit impulsive, while seeing the old man first would mean one is honest, faithful, and goal-oriented.

But is there any actual science to back up the current fad? There is not, according to a paper published in the journal PeerJ, whose authors declare these kinds of personality quizzes to be a new kind of psychological myth. That said, they did find a couple of intriguing, statistically significant correlations they believe warrant further research.

In 1892, a German humor magazine published the earliest known version of the "rabbit-duck illusion," in which one can see either a rabbit or a duck, depending on one's perspective—i.e., multistable perception. There have been many more such images produced since then, all of which create ambiguity by exploiting certain peculiarities of the human visual system, such as playing with illusory contours and how we perceive edges.

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Lenovo’s Yoga Solar PC Concept Laptop is… an idea, I guess

Lenovo has a habit of designing weird laptop concepts as a way to push the boundaries of what you can do with a mobile computer. Sometimes the company even brings its weird laptops to market. And the new Lenovo Yoga Solar PC Concept is probably less we…

Lenovo has a habit of designing weird laptop concepts as a way to push the boundaries of what you can do with a mobile computer. Sometimes the company even brings its weird laptops to market. And the new Lenovo Yoga Solar PC Concept is probably less weird than some. That said, I can’t help but […]

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Apple refuses to break encryption, seeks reversal of UK demand for backdoor

Apple appeal to Investigatory Powers Tribunal may be the first case of its type.

Apple reportedly filed an appeal in hopes of overturning a secret UK order requiring it to create a backdoor for government security officials to access encrypted data.

"The iPhone maker has made its appeal to the Investigatory Powers Tribunal, an independent judicial body that examines complaints against the UK security services, according to people familiar with the matter," the Financial Times reported today. The case "is believed to be the first time that provisions in the 2016 Investigatory Powers Act allowing UK authorities to break encryption have been tested before the court," the article said.

A Washington Post report last month said UK security officials "demanded that Apple create a backdoor allowing them to retrieve all the content any Apple user worldwide has uploaded to the cloud," including "blanket capability to view fully encrypted material."

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Google’s AI-powered Pixel Sense app could gobble up all your Pixel 10 data

The app will reportedly offer contextual suggestions as you use the phone.

Google's AI ambitions know no bounds. A new report claims Google's next phones will herald the arrival of a feature called Pixel Sense that will ingest data from virtually every Google app on your phone, fueling a new personalized experience. This app could be the premiere feature of the Pixel 10 series expected out late this year.

According to a report from Android Authority, Pixel Sense is the new name for Pixie, an AI that was supposed to integrate with Google Assistant before Gemini became the center of Google's universe. In late 2023, it looked as though Pixie would be launched on the Pixel 9 series, but that never happened. Now, it's allegedly coming back as Pixel Sense, and we have more details on how it might work.

Pixel Sense will apparently be able to leverage data you create in apps like Calendar, Gmail, Docs, Maps, Keep Notes, Recorder, Wallet, and almost every other Google app. It can also process media files like screenshots in the same way the Pixel Screenshots app currently does. The goal of collecting all this data is to help you complete tasks faster by suggesting content, products, and names by understanding the context of how you use the phone. Pixel Sense will essentially try to predict what you need without being prompted.

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Nothing Phone (3a) and (3a) Pro feature Snapdragon 7s Gen 3 and triple cameras for $379 and up

Many of today’s mid-range smartphones offer the kind of performance you would have expected from a flagship a few years ago. But it’s not just performance that’s gone up – many phone makers have also increased starting prices. C…

Many of today’s mid-range smartphones offer the kind of performance you would have expected from a flagship a few years ago. But it’s not just performance that’s gone up – many phone makers have also increased starting prices. Case in point: Apple recently replaced the iPhone SE ($429 starting price) with a new iPhone 16e […]

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