RNA vaccines seem to produce very different antibody levels

Result raises questions about correlation between protection and antibody levels.

Image of a woman taking a blood sample from a seated person.

Enlarge / A phlebotomist draws blood meant for antibody testing. (credit: Frederic J. Brown / Getty Images)

We've tended to treat the RNA-based vaccines from Moderna and Pfizer/BioNTech as functionally equivalent. They take an identical approach to producing immunity and have a very similar set of ingredients. Clinical trial data suggested they had very similar efficacy—both in the area of 95 percent.

So it was a bit of a surprise to have a paper released yesterday indicating that the two produce an antibody response that's easy to distinguish, with Moderna inducing antibody levels that were more than double that seen among people who received the Pfizer/BioNTech shot. While it's important not to infer too much from a single study, this one was large enough that the results are likely to be reliable. If so, the results serve as a caution that we might not want to base too many of our expectations on relatively crude measures of antibody levels.

The new study

The work itself was remarkably simple. A Belgian medical center was vaccinating its staff and asked for volunteers willing to give blood samples. Samples were taken both prior to vaccination and six to 10 weeks after, with the levels of antibody specific to the SARS-CoV-2 spike protein tested at both points. About 700 participants received the Moderna vaccine, while roughly 950 took the one from Pfizer/BioNTech.

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Lilbits: Steam Deck battery life estimates, Bose and Jabra’s new headphones, and Amazon’s live audio ambitions

Bose is updating its iconic QuietComfort noise-cancelling headphones with a new pair that… looks a lot like the old pair, but which has improved noise cancellation technology and longer battery life. And if earbuds are more your style, Jabra is …

Bose is updating its iconic QuietComfort noise-cancelling headphones with a new pair that… looks a lot like the old pair, but which has improved noise cancellation technology and longer battery life. And if earbuds are more your style, Jabra is launching three new pairs, including its first budget earbuds priced below $80 and new premium […]

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Filmmakers Request U.S. Blocking Order Against Popcorn Time Domains

A group of independent movie companies ha asked a Virginia federal court to grant millions in copyright damages against a popular fork of the piracy app Popcorn Time. The request for a default judgment also comes with a far-reaching injunction which, among other things, would require Internet providers to block several Popcorn Time domains.

From: TF, for the latest news on copyright battles, piracy and more.

popcornFor more than seven years, Popcorn Time has been a thorn in the side of movie studios large and small.

The ‘Netflix for Pirates’ offers an easy-to-use application that opens the door to a library of thousands of streamable movies and TV shows.

Legal Issues

The Motion Picture Association (MPA) recognized this threat early on and pressured the original developers to throw in the towel. That worked, but it came too late as the open-source project was swiftly revived by others.

Popcorn Time lived on through many project forks, including PopcornTime.app, which carried on from where the original developers stopped. However, the fork’s developers haven’t been spared from legal pressure.

Last year, Hawaiian anti-piracy attorney Kerry Culpepper registered the “Popcorn Time’ trademark, which he used to get Popcorn Time’s Twitter account suspended. Around the same time, Github removed the Popcorn Time repository following a complaint from the MPA, a decision that was later reversed.

Movie Companies Sue Popcorn Time

A few months ago, a group of independent movie companies, including the makers of “The Hitman’s Bodyguard” and “London Has Fallen,” increased the pressure. The filmmakers sued the anonymous PopcornTime.app operator, together with the VPN service VPN.ht.

According to a recent court filing, VPN.ht and the filmmakers are close to signing a settlement agreement. However, the same can’t be said for the anonymous “Popcorn Time” operator, who failed to respond in court.

Soon after the lawsuit was filed, the official PopcornTime.app site disappeared. The official Reddit community also went private, but not before one of the moderators posted a message, pointing people to popcorn-ru.tk/build/, which remains online today.

Millions in Damages

The movie companies kept a close eye on these developments and remain determined to shut the fork down once and for all. Without a formal response from the developers, they are now asking the court to issue a default judgment, awarding millions of dollars for various copyright and trademark violations.

The list of demands is long. Among other things, the filmmakers demand the maximum statutory copyright infringement damages for 21 movie titles. This adds up to a healthy $3,150,000.

That’s not all, Popcorn Time trademark owner 42 Ventures joined the lawsuit as well. The company, which lists lawyer Kerry Culpepper as its director, demands $2 million in damages for trademark infringement.

The requested damages amount is sufficient to bankrupt most people. However, the default judgment also comes with a request for an injunction, which could potentially have much broader consequences.

Site Blocking and More

The proposed injunction would require ISPs to block access to several Popcorn Time domain names, including popcorn-ru.tk. Thus far, no federal court has issued such a blocking order in a piracy case, but the filmmakers argue that this is an option under the DMCA.

Specifically, Section 512 of the DMCA allows for an order that required Internet providers “to block access, to a specific, identified, online location outside the United States.”

The movie companies believe that such a blocking order is warranted in this case. In their proposed order, which has yet to be approved by the court, they use the following terminology:

It is ORDERED that, within 60 days receipt of this order, all Internet Service Providers (“ISPs”) subject to personal jurisdiction of the United States use their best technical efforts to BLOCK access on their servers or servers under their control to the following Target Domain Names at which Defendant’s movie piracy app Popcorn Time is distributed: http://popcorn-ru.tk; https://popcorn-time.tw/; and https://popcorntime-online.ch/.

The targeted ISPs, which could include Comcast, Verizon, and AT&T, can use a variety of blocking options, according to the rightsholders. This includes blocking domain names and IP-addresses.

The requested injunction doesn’t stop there. The movie companies also want third-party service providers such as Cloudflare and Google to stop people from accessing Popcorn Time domains. This includes the removal of all search engine results.

In addition, the rightsholders seek an order that requires the developer platform GitHub to take the Popcorn Time repository and various related accounts offline.

Movie Studios’ Proposed Order

github popcorn

As mentioned before, these requests are made as part of a motion for a default judgment. This means that the defendant is not represented in court, which makes it more likely that the court will approve the request.

Unavoidable Blocking Battle?

Given what is at stake here, however, it’s certainly possible that – if the order is granted – some of the third-party intermediaries will object. After all, some of these requests are quite novel.

The movie studios’ site-blocking request is not entirely new. Over the past weeks, the same companies have listed similar demands in lawsuits against Internet providers such as Grande Communications, RCN, and WOW!.

All in all, it seems likely that the site-blocking issue will be properly tested in U.S. courts in the near future.

A copy of the motion for a default judgment, submitted at the US District Court for the Eastern District of Virginia, is available here (pdf)

From: TF, for the latest news on copyright battles, piracy and more.

GM throws LG under the bus as Chevy Bolt production pauses amid recall

No end in sight for recall as both companies race to find the problem.

GM throws LG under the bus as Chevy Bolt production pauses amid recall

(credit: Jeffrey Sauger / Chevrolet)

General Motors has lost confidence in battery supplier LG Chem after defective cells from the company caused a string of fires and sparked a massive recall of Chevrolet Bolt electric vehicles and electric utility vehicles.

The automaker recalled more than 140,000 electric cars and crossovers—every single one that the company has made—when it discovered two simultaneously occurring defects in the LG-made batteries. GM suspects the defects are behind the 10 fires the company has identified so far.

LG Chem makes the battery packs for every Chevy Bolt, and while the problem was initially traced to one of LG's Korean plants, subsequent investigations revealed that other LG plants were pumping out bad cells, too.

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System76 Pangolin Linux laptop now available with Ryzen 5000U

The Pangolin laptop is a thin and light notebook from Linux PC maker System76. Available with a choice of Ubuntu or Pop!_OS software, the notebook has a 15.6 inch full HD display, support for up to 64GB of RAM and 2TB of storage. And the Pangolin only…

The Pangolin laptop is a thin and light notebook from Linux PC maker System76. Available with a choice of Ubuntu or Pop!_OS software, the notebook has a 15.6 inch full HD display, support for up to 64GB of RAM and 2TB of storage. And the Pangolin only weighs about 3.6 pounds and measures less than […]

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MGM releases last trailer for No Time to Die, Daniel Craig’s final 007 film

“Every mission, every sacrifice has led to this.”

One of the first major films to be postponed due to the pandemic was No Time to Die, Daniel Craig's final outing as 007. Originally slated for an April 2020 release, the film was first postponed until November 2020 and then delayed again until April 2021. While some theaters remain closed around the world, MGM is sticking with its latest release dates: a world premiere at Royal Albert Hall in London on September 28, 2021, followed by a general release on September 30 in the UK and October 8 in the US. And the studio has released one last trailer to remind audiences that yes, this premiere is finally happening.

(Spoilers for the 2015 film Spectre below.)

As we've reported previously, this 25th installment in the franchise is co-produced by MGM and Eon Productions, with United Artists and Universal serving as distributors in North America and internationally, respectively. Directed by Cary Joji Fukunaga (True Detective, Beast of No Nation), the film takes place about five years after the capture of Spectre's archvillain Ernst Stavro Blofeld (Christoph Waltz), a criminal mastermind and head of the organization SPECTRE. (Ian Fleming's original character inspired Dr. Evil and his cat, Mr. Bigglesworth, in the Austin Powers film series.)

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Samsung Galaxy Book Fold 17 could be a laptop with a foldable OLED display

Samsung has been selling smartphones with foldable OLED displays for a few years. Now the company may be preparing to launch a laptop that uses similar technology. According to @UniverseIce, a Samsung Galaxy Book Fold 17 is in the works. And if you wa…

Samsung has been selling smartphones with foldable OLED displays for a few years. Now the company may be preparing to launch a laptop that uses similar technology. According to @UniverseIce, a Samsung Galaxy Book Fold 17 is in the works. And if you want an idea of what it would could look like, Samsung has you covered […]

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Daily Deals (8-31-2021)

Toward the start of the global COVID-19 pandemic, there was a webcam shortage as folks bought up all the available supply of cameras to participate in endless Zoom calls. These days it’s a lot easier to find a halfway decent model for a reasonab…

Toward the start of the global COVID-19 pandemic, there was a webcam shortage as folks bought up all the available supply of cameras to participate in endless Zoom calls. These days it’s a lot easier to find a halfway decent model for a reasonable price. And today you can score one of the best deals […]

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