Month: May 2024

Enlarge / The spliceosome is a large complex of proteins and RNAs. (credit: NCBI)

Almost 1,500 genes have been implicated in intellectual disabilities; yet for most people with such disabilities, genetic causes remain unknown. Perhaps this is in part because geneticists have been focusing on the wrong stretches of DNA when they go searching. To rectify this, Ernest Turro—a biostatistician who focuses on genetics, genomics, and molecular diagnostics—used whole genome sequencing data from the 100,000 Genomes Project to search for areas associated with intellectual disabilities.

His lab found a genetic association that is the most common one yet to be associated with neurodevelopmental abnormality. And the gene they identified doesn’t even make a protein.

Trouble with the spliceosome

Most genes include instructions for how to make proteins. That’s true. And yet human genes are not arranged linearly—or rather, they are arranged linearly, but not contiguously. A gene containing the instructions for which amino acids to string together to make a particular protein—hemoglobin, insulin, serotonin, albumin, estrogen, whatever protein you like—is modular. It contains part of the amino acid sequence, then it has a chunk of DNA that is largely irrelevant to that sequence, then a bit more of the protein’s sequence, then another chunk of random DNA, back and forth until the end of the protein. It’s as if each of these prose paragraphs were separated by a string of unrelated letters (but not a meaningful paragraph from a different article).

Enlarge (credit: NurPhoto / Contributor | NurPhoto)

The New York Times is fighting to take down a game called Worldle, according to a legal filing viewed by the BBC, in which The Times apparently argued that the geography-based game is "creating confusion" by using a name that's way too similar to Wordle.

Worldle is "nearly identical in appearance, sound, meaning, and imparts the same commercial impression" to Wordle, The Times claimed.

The Times bought Wordle in 2022, paying software developer Josh Wardle seven figures for the daily word-guessing puzzle game after its breakout success during the pandemic. Around the same time, Worldle was created—along with more than 100 other Wordle spinoffs offering niche alternatives to Wordle, including versions in different languages and completely different games simply using the name construction ending in "-le." The Times filed for a Wordle trademark the day after buying the game and by March 2022, it started sending takedown requests.

Enlarge / Jeep is ready to join the electric SUV fray with the new Wagoneer S, which goes on sale later this year. (credit: Jeep)

The Jeep brand has finally debuted its first purpose-built electric vehicle. It's targeting the hotly contested SUV segment with the new Wagoneer S, which goes on sale this fall. But other than its name, it shares little with the gasoline-powered Wagoneer; the Wagoneer S uses the same EV architecture—called STLA Large—as the forthcoming electric Dodge Charger.

It looks like Jeep is using a similar playbook to Dodge and Ram as it introduces its electric models: Give them the same name and styling as a familiar bestseller to keep customers comfortable, then give them serious power output and some headline-grabbing numbers to generate a halo effect.

Powerful

That's why the Jeep Wagoneer S Launch Edition will offer 600 hp (447 kW), 617 lb-ft (837 Nm), and a 0–60 mph (0-98 km/h) time of 3.4 seconds. It's powered by a 100.5 kWh battery pack with nickel manganese cobalt chemistry operating at 400 V.