mRNA technology for vaccines and more: An Ars Frontiers recap

The tech has lots of applications beyond the one we’ve already been injected with.

Ars' John Timmer (left) with Karin Bok (center) and Nathaniel Wang (right).

Enlarge / On May 22, John Timmer (left) moderated a panel featuring Karin Bok (center) and Nathaniel Wang (right) for the Ars Frontiers 2023 session titled, "Beyond COVID: What Does mRNA Technology Mean for Disease Treatment?" (credit: Ars Technica)

The world of biomedicine has developed a lot of technology that seems a small step removed from science fiction, but the public isn't aware of much of it. mRNA-based vaccines, though, were a big exception as a lot of the public tracked the technology's development as a key step toward emerging from the worst of the pandemic and then received the vaccines in droves.

mRNA technology has a lot of potential applications beyond COVID, and we talked a bit about those during the "Beyond COVID: What Does mRNA Technology Mean for Disease Treatment?" panel at last week's Ars Frontiers event. We've archived the panel on YouTube; if you want to focus on the discussion about mRNA therapies, you can start at the 1-hour, 55-minute mark.

mRNA is a nucleic acid molecule that instructs the cell to make specific proteins. When used as vaccines, the instructions call for a protein produced by a pathogen, such as a virus. "It helps put up a wanted poster for the immune system," was how Nathaniel Wang, co-founder and CEO of Replicate Bioscience put it.

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Beating the heat: These plant-based iridescent films stay cool in the sun

Cellulose is sustainable, biocompatible, and ideal for radiative cooling applications.

A colorful, textured bi-layer film made from plant-based materials cools down when it’s in the sun.

Enlarge / A colorful, textured bi-layer film made from plant-based materials cools down when it’s in the sun. (credit: Qingchen Shen)

Summer is almost here, bringing higher temperatures and prompting many of us to crank up the air conditioning on particularly hot days. The downside to A/C is that the units gobble up energy and can emit greenhouse gases, contributing further to global warming. Hence, there is strong interest in coming up with eco-friendly alternatives. Scientists from the University of Cambridge have developed an innovative new plant-based film that gets cooler when exposed to sunlight, making it ideal for cooling buildings or cars in the future without needing any external power source. They described their work at a recent meeting of the American Chemical Society.

The technical term for this approach is passive daytime radiative cooling (PDRC), so named because it doesn't require an injection of energy into the system to disperse heat. The surface emits its own heat into space without being absorbed by the air or atmosphere, thereby becoming several degrees cooler than the surrounding air without needing electrical energy.

"We know there is spontaneous thermal transfer between objects with different temperatures," Qingchen Shen said at a press conference during the meeting. Their cooling technology exploits that thermal transfer, with a twist. Most PDRC materials (paints, films, and so forth) are white, or have a mirrored finish, to achieve a broadband reflection of sunlight. Pigments or dyes interfere with that since they absorb specific wavelengths of light and only reflect certain colors, thereby transforming energy from the light into heat. The films created by Shen et al. are colored, but it is structural color in the form of nanocrystals, not due to adding pigments or dyes. So color can be added without sacrificing the passive cooling efficiency.

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What to expect at WWDC 2023: Reality Pro, iOS 17, and new MacBooks

Apple is set to announce its first new major platform in years.

Futuristic glass-walled building permits views of surrounding forest.

Enlarge / Inside the Steve Jobs Theater building at Apple's headquarters. (credit: Samuel Axon)

Apple's 2023 Worldwide Developer Conference is just a few days away—it kicks off with a keynote on Monday, June 5. That keynote will be livestreamed (we'll liveblog it, too), and it's expected to be a doozy.

The WWDC keynote isn't always the most exciting for non-developers, as it usually focuses on iOS updates rather than exciting new hardware. There have been exceptions, though, and next week's event will surely be one of them. Apple is expected to finally unveil its rumored mixed reality headset, which has taken a long and winding path to market.

That will be the main focus, but there will be interesting new developments on the iPhone, Mac, and Watch. Here's what to expect from the WWDC keynote next week.

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Arm announces the Cortex X4 for 2024, plus a 14-core M2-fighter

Will anyone build Arm’s 14-core mega chip? Will Arm have to do it itself?

Over the weekend, Arm showed off its vision for the next generation of flagship CPUs. As usual, these designs include CPUs in various sizes for different workloads. The 'big' chip this year is the Arm Cortex X4, the 'medium' chip is the Cortex A720, and the 'small' chip is the Cortex A520. The new chips should arrive in Android phones and Windows laptops in 2024.

Arm claims the big Cortex X3 chip will have 15 percent higher performance than this year's X3 chip, and "40 percent better power efficiency." The company also promises a 20 percent efficiency boost for the A700 series and a 22 percent efficiency boost for the A500.

The new chips are all built on the new 'Armv9.2' architecture, which adds a "new QARMA3 algorithm" for Arm's Pointer Authentication memory security feature. Pointer authentication assigns a cryptographic signature to memory pointers and is meant to shut down memory corruption vulnerabilities like buffer overflows by making it harder for unauthenticated programs to create valid memory pointers. This feature has been around for a while, but Arm's new algorithm reduces the CPU overhead of all this extra memory work to just 1 percent of the chip's power, which hopefully will get more manufacturers to enable it.

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Elizabeth Holmes has reported to prison in Texas to start her 11-year sentence

Elizabeth Holmes arrived at the minimum-security prison camp in Bryan, Texas.

Elizabeth Holmes, founder of Theranos Inc., center, arrives at Federal Prison Camp Bryan in Bryan, Texas, US, on Tuesday, May 30, 2023. Holmes surrendered to authorities on Tuesday to begin her 11 1/4-year sentence after she was convicted by a jury last year of defrauding investors in the blood-testing startup. Photographer: Sergio Flores/Bloomberg via Getty Images

Enlarge / Elizabeth Holmes, founder of Theranos Inc., center, arrives at Federal Prison Camp Bryan in Bryan, Texas, US, on Tuesday, May 30, 2023. Holmes surrendered to authorities on Tuesday to begin her 11 1/4-year sentence after she was convicted by a jury last year of defrauding investors in the blood-testing startup. Photographer: Sergio Flores/Bloomberg via Getty Images (credit: Getty | Bloomberg)

Disgraced biotech entrepreneur Elizabeth Holmes has arrived at a federal prison in Texas to begin her 11-year, three-month sentence for defrauding investors of her defunct blood-testing start-up, Theranos.

Press and photographers stationed outside the women's prison camp in Bryan, Texas, captured what appeared to be Holmes exiting a gray SUV with New York state plates and making her way into the facility flanked by facility staff at around 12:30 pm local time. Shortly afterward, the Federal Bureau of Prisons confirmed to the Associated Press that Holmes was indeed in custody at the facility, FPC Bryan, which is about 100 miles northwest of Houston, Texas.

The facility houses about 655 female inmates who are required to work in the cafeteria or a manufacturing facility, with pay starting at $1.15 per hour, according to The New York Times. Like other inmates, Holmes will don prison-issued khaki pants and shirts in pastel green, gray, or white during her stay. She will have no Internet access but can buy a radio or an MP3 player from the prison commissary and listen to "non-explicit" music. When she's not working or listening to prison-approved music, she can partake in leisure activities such as "table games" and arts and crafts.

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AYA Neo 2S with Mini LED display and Ryzen 7 7840U is under development (handheld gaming PCs)

The AYA Neo 2S is a handheld gaming PC with a 7 inch, 1920 x 1200 pixel IPS LCD display, an AMD Ryzen 7 7480U processor, and support for up to 64GB of RAM and 4TB of storage. But if that’s not enough of a spec-overload for you, AYA is teasing an…

The AYA Neo 2S is a handheld gaming PC with a 7 inch, 1920 x 1200 pixel IPS LCD display, an AMD Ryzen 7 7480U processor, and support for up to 64GB of RAM and 4TB of storage. But if that’s not enough of a spec-overload for you, AYA is teasing an upcoming model that […]

The post AYA Neo 2S with Mini LED display and Ryzen 7 7840U is under development (handheld gaming PCs) appeared first on Liliputing.

Lawyer cited 6 fake cases made up by ChatGPT; judge calls it “unprecedented”

Judge weighs punishment for lawyer who didn’t bother to verify ChatGPT output.

Robotic hand points to a line on a document while a human signs it with a pen. A judge's gavel is in the background.

Enlarge (credit: Getty Images | Andrey Popov)

A lawyer is in trouble after admitting he used ChatGPT to help write court filings that cited six nonexistent cases invented by the artificial intelligence tool.

Lawyer Steven Schwartz of the firm Levidow, Levidow, & Oberman "greatly regrets having utilized generative artificial intelligence to supplement the legal research performed herein and will never do so in the future without absolute verification of its authenticity," Schwartz wrote in an affidavit on May 24 regarding the bogus citations previously submitted in US District Court for the Southern District of New York.

Schwartz wrote that "the use of generative artificial intelligence has evolved within law firms" and that he "consulted the artificial intelligence website ChatGPT in order to supplement the legal research performed."

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Flawless IPTV: Men Behind UK’s Largest Pirate Service Jailed For 30+ Years

Five men behind pirate IPTV service ‘Flawless’ were sentenced to more than 30 years in prison today, after a private prosecution by the Premier League. A FACT test purchase in 2017 led to the involvement of four territorial police forces, three regional Trading Standards units, and the arrest of service kingpin, Mark Gould, in 2018. In less than two years, Flawless served over 50,000 UK households while generating millions in revenue.

From: TF, for the latest news on copyright battles, piracy and more.

flawless-logo1Operating from 2016 until 2018, the Flawless IPTV service copied subscription TV broadcasts from official (and unofficial) sources and then restreamed that content to tens of thousands of customers, at a dramatically cut down price.

For many UK football fans, Flawless granted access to the sport they love, at a price they could afford. Others viewed the service quite differently.

From the Premier League’s perspective, Flawless was a fraudulent, criminal enterprise that stole potential revenue from the country’s leading football clubs. Through its illegal participation in the subscription TV market, Flawless had a direct impact on Sky and Virgin Media subscription package sales.

More broadly, Flawless undermined the Premier League’s right to offer exclusive broadcasting licenses in the UK and that had the potential to affect how much broadcasters were prepared to pay for those licenses.

Today’s Sentencing Hearing

Following an extraordinarily deep and costly investigation, and a five-year Premier League private prosecution, five men behind the UK’s largest-ever piracy service were sentenced today at Chesterfield Justice Centre.

Mark Gould, Steven Gordon, Peter Jolley, Christopher Felvus and William Brown were sentenced to more than 30 years in prison combined. A sixth defendant, Zak Smith, did not appear in court.

In total, Flawless operated for just 22 months but still managed to generate an estimated £4.6 million in revenue. £3.7 million of that was profit, split very unequally between those sent to prison today.

Mark Gould, 36, was the driving force behind Flawless. His share of the profit was around £1.7 million. Today he received an unprecedented 11-year sentence on two counts of conspiracy to defraud and contempt of court.

Steven Gordon’s cut was significant too, roughly £1 million according to the prosecution. Two counts of conspiracy to defraud and contempt of court led to a sentence of five years and two months.

Peter Jolley’s share of the profit was reported as £773,000. He received a sentence of five years and two months, on two counts of conspiracy to defraud and money laundering.

Christopher Felvus’ share was a relatively modest £164,500. Two counts of conspiracy to defraud earned him a sentence of three years and 11 months.

William Brown made just £15,000 but after pleading not guilty and then losing his case, today he was sentenced to four years and nine months, on two counts of conspiracy to defraud.

Zak Smith appears to have made less than £5,000 from Flawless. He did not appear in court today and a warrant was issued for his arrest.

What follows are just some of the events that led to the men being sentenced today, including why Flawless was so successful, and how it all fell apart.

Flawless Won Fans By Exploiting a Restricted Market, Fraudulently

Top-tier football matches in England take place in the Premier League, a league operated by a company of the same name, owned by the clubs that play in it.

Premier League broadcasting rights cost billions, so when broadcasters like Sky and Virgin hand over their share of the cash for exclusive local rights, recouping that cash from UK football fans is reflected in costly subscription package prices.

For cash-strapped football fans in the UK, pirate IPTV providers represent choice and affordability in a market where very little exists. Subscriptions available at a fraction of the official cost are a huge draw but the elephant in the room is unavoidable.

Pirate IPTV services cost less and offer more, but that’s only because they pay nothing to rightsholders like the Premier League, while paying nothing to broadcasters whose transmissions they copy.

The end result of an aggressive Premier League private prosecution spanning five years, the sentences handed down today show that undermining corporations worth billions has the potential to end in complete catastrophe for IPTV operators. It also ends badly for football fans and the public in general.

While this was a private prosecution, the Premier League – and by extension Premier League clubs – will now recoup the costs of the investigation and prosecution from the Crown, meaning that tax paying football fans and taxpayers in general will pick up an incredibly large bill.

Flawless IPTV

Launched around August 2016, Flawless IPTV began as a three-way partnership consisting of Mark Gould, Steven Gordon, and Peter Jolley, all of whom had parted ways with another IPTV provider, known online as Overlords. Christopher Felvus, who was also active in the pirate IPTV scene, made up the quartet and for Flawless, it was game on.

In common with licensed services, pirate IPTV providers have broadly two options for reaching the market. Selling subscriptions directly to consumers makes the most money on paper but also causes the most headaches. Selling to customers via resellers makes considerably less, but in many cases a 40% cut may be considered worth it.

Flawless decided to cover both angles by selling direct from its own website and social medias, and also indirectly via a network of resellers.

With a heavy focus on Premier League content, particularly matches broadcast during the UK’s ‘3pm blackout’, Flawless and success went hand in hand. A big hit with football fans, the IPTV service went from strength to strength with a comprehensive, mostly reliable product, for just £10 per month. For a while, everything went broadly to plan.

Numerous behind-the-scenes dramas, some worthy of a TV series in their own right, kept the business on its toes in the months to come. Yet after signing up thousands of customers with no notable issues, a subscription purchased in 2017 sparked a massive criminal investigation and marked the beginning of the end for the entire service.

Charity Received Complaints

Crimestoppers, a UK charity famous for its anonymous tip lines, is said to have received complaints about Flawless in the summer of 2017. Instead of contacting the police, Crimestoppers alerted the Federation Against Copyright Theft (FACT) which led to a covert purchase of a Flawless subscription in October of the same year.

After concluding that Flawless offered streams broadcast by Sky and Virgin, among others, FACT leveraged its connections in government, law enforcement agencies, and civil authorities, calling for action to defend the Premier League’s rights.

A report to GAIN, the Government Agency Intelligence Network, led to the allocation of significant public resources. With the support of a dedicated financial investigator, a senior Trading Standards officer took over the investigation and a little over six months later, Flawless was all but finished.

Mark Gould Arrested First, Others follow

In May 2018, search warrants were executed at two addresses in London. Gould was arrested at his home in Greenwich, an apartment on the river recently purchased for £600,000 – cash.

Around a month later the authorities arrested Steven Gordon and Peter Jolley, and three weeks after that Christopher Felvus was detained. William Brown and Zak Smith were arrested early August 2018 but it would be another five months before the case was submitted to the court, and another three years before today’s sentencing.

Profitable Business, But Not For All

In total, Flawless operated for just 22 months but still managed to generate an estimated £4.6 million in revenue, £3.7 million of that in profit. As highlighted earlier, Gould is said to have made most from the operation, around £1.7 million.

William Brown made almost nothing from Flawless yet today received a sentence roughly on par with that handed to Steven Gordon, who made more than £1 million from the operation and was also held in contempt of court. In common with all of the defendants sentenced today, Brown had no previous convictions.

Warrant Issued For Arrest of Zak Smith

This curious anomaly leads us to Zak Smith, his apparent absence from court today, and a warrant for his arrest. Smith made roughly three times less than Brown, around £5,000, but was expected to receive a similar sentence today. The reasons for that are extraordinary.

The details of Smith’s involvement aren’t just interesting, they are arguably worthy of a Netflix drama series in their own right. Smith worked at anti-piracy company Friend MTS, known for working with the Premier League to ensure that pirate services are blocked by ISPs during match times.

This type of blocking is authorized by High Court injunction, the finer details of which are closely guarded secrets. Or at least that’s the usual plan. In some cases blocking programs appear suddenly ineffective, with services like Flawless operating broadly as usual, with Flawless competitors not doing anywhere near as well.

We’ll return to that story very soon and reveal how the dismantling of Flawless was interpreted as a prompt to launch more IPTV services that made even more money.

From: TF, for the latest news on copyright battles, piracy and more.

Dallas airport will demo this cute little mobile EV charging robot

Instead of making the EVs park by a charger, this charger can come to the EV.

A mobile EV charger recharges a white BMW iX

Enlarge / Ziggy is a battery-powered EV charger on wheels that can come visit individual parking spaces to recharge EVs where they park. (credit: EV Safe Charge)

There are a few things we need to work on if we're going to properly embrace the electric vehicle revolution. More batteries, for one—tight supplies mean automakers can only build enough EVs to satisfy some of the pent-up demand. Cheaper EVs would be helpful, too, considering that by the end of 2022 the average cost of a new EV was more than $61,000. And charging infrastructure needs to improve, too. Now, a new mobile EV charger called Ziggy might help with that last one.

Installing EV chargers usually isn't too difficult if you're a homeowner with a garage or carport, but things can get more complicated for multifamily dwellings and commercial parking premises. Permitting is often a big problem, and there can also be lengthy waits to get electrical infrastructure upgraded, particularly if the plan is to install level 3 DC fast chargers, which can suck up 100s of kWs of electricity from the grid.

Ziggy is the work of the company EV Charge Safe, and it flips the idea of EV charging on its head. Instead of a driver parking by the EV charger, Ziggy is mobile and can come to the car instead.

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Microsoft drops Surface Pro X webcam quality to get broken cameras working again

Microsoft working with OEMs on permanent driver fix for Windows-on-Arm devices.

Surface Pro X

Enlarge / The Microsoft Surface Pro X. (credit: Jeff Dunn)

Microsoft has issued a workaround for broken Surface Pro X cameras following user reports that the integrated webcams stopped working on May 23. The tech giant says it's working with OEM partners to fix the problem permanently.

Microsoft debuted the Surface Pro X in 2019. The tablet, focusing on battery life and mobility, opted for a Microsoft-branded SQ1 processor, based off Qualcomm's first-generation Snapdragon 8cx. An SQ2 version succeeded. In October 2022, Microsoft announced the Surface Pro 9, which includes Arm options and, thus, essentially absorbs the Surface Pro X.

But there are still plenty of people with a Surface Pro X (Microsoft doesn't disclose Surface sales numbers specifically, but the Surface business overall brought in $6.7 billion in revenue last fiscal year), and as of May 23, all of their built-in webcams stopped working.

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