Mysteries of the poisonous amphibians

How do frogs and other amphibians survive their own noxious weapons?

poison dart frog on a leaf

Enlarge / A Granular Poison Frog (Oophaga granulifera) sits on the edge of a leaf. (credit: Paul Osborne via Getty Images)

From the brightly colored poison frogs of South America to the prehistoric-looking newts of the Western US, the world is filled with beautiful, deadly amphibians. Just a few milligrams of the newt’s tetrodotoxin can be fatal, and some of those frogs make the most potent poisons found in nature.

In recent years, scientists have become increasingly interested in studying poisonous amphibians and are starting to unravel the mysteries they hold. How is it, for example, that the animals don’t poison themselves along with their would-be predators? And how exactly do the ones that ingest toxins in order to make themselves poisonous move those toxins from their stomachs to their skin?

Even the source of the poison is sometimes unclear. While some amphibians get their toxins from their diet, and many poisonous organisms get theirs from symbiotic bacteria living on their skin, still others may or may not make the toxins themselves — which has led scientists to rethink some classic hypotheses.

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Ars Technica System Guide: Four PC builds for spring 2023

New CPUs and GPUs and low RAM and SSD prices change many of our recommendations.

Ars Technica System Guide: Four PC builds for spring 2023

Enlarge (credit: NZXT)

It's a weird time to build a PC. That's partly because fewer people are doing it—sales for parts and prebuilt PCs are down across the industry, as people continue to make do with the stuff they bought early in the pandemic. And GPU prices, while closer to "normal" than they have been over the last two years, are still historically high.

But that doesn't mean it's a bad time to build a PC. Storage and memory are mostly cheap, and you can buy a lot of CPU power for not a lot of money (especially if what you're used to is an older quad-core processor you picked up five or six years ago). Intel and AMD have also released new CPUs since our last system guide update in July, and Intel has finally jumped into the GPU business after years of false starts and delays.

It's as good a time as any for a new version of our PC building guide, so we've put together four different sample builds focused on different budgets and use cases. You can buy the specific components we recommend and get a good, functional PC, or you can use them as starting points and make changes based on what you want and need.

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KI gegen Verschlüsselung: Diese SSD soll sich gegen Ransomware schützen

Kommt die KI zu dem Schluss, dass gerade der Inhalt der SSD verschlüsselt wird, kann sie den Zugriff verbieten. Der Hersteller verspricht, dass dies weitgehend zuverlässig funktioniert. (Speichermedien, Solid State Drive)

Kommt die KI zu dem Schluss, dass gerade der Inhalt der SSD verschlüsselt wird, kann sie den Zugriff verbieten. Der Hersteller verspricht, dass dies weitgehend zuverlässig funktioniert. (Speichermedien, Solid State Drive)

UK government blocks Microsoft’s proposed Activision purchase

Gov. group says deal would “substantially lessen competition” in cloud gaming.

A magnifying glass inspects a surface covered in various corporate logos.

Enlarge / Taking a close look... (credit: Aurich Lawson / Ars Technica)

In its long-awaited final report, the United Kingdom's Competition and Markets Authority said that Microsoft's proposed $69 billion acquisition of Activision would "result in a substantial lessening of competition" (SLC) in the supply of cloud gaming services in the UK." As such, the regulator said that "the only effective remedy to this SLC and its adverse consequences is to prohibit the Merger."

The final report cites Microsoft's "strong position" in the cloud gaming sector, where the company has an estimated 60 to 70 percent market share that makes it "already much stronger than its rivals." After purchasing Activision, the CMA says Microsoft "would find it
commercially beneficial to make Activision’s titles exclusive to its own cloud gaming service."

Microsoft has in recent months signed deals with Nvidia and smaller cloud gaming providers in an attempt to "mak[e] even more clear to regulators that our acquisition of Activision Blizzard will make Call of Duty available on far more devices than before," as Microsoft Vice Chair and President Brad Smith said in a statement last month. But the CMA said these kinds of cloud-gaming deals—which Microsoft submitted to the CMA as a proposed remedy for any anticompetitive effects of the merger—were "limited to cloud gaming providers with specific business models" and thus not sufficient to address the regulator's concerns.

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Preiskampf: Alibaba Cloud halbiert die Preise

Clouddienste des chinesischen Anbieters kosten ab nächstem Monat bis zu 50 Prozent weniger. Die radikale Preissenkung soll das Geschäft wachsen lassen. (Alibaba, Cloud Computing)

Clouddienste des chinesischen Anbieters kosten ab nächstem Monat bis zu 50 Prozent weniger. Die radikale Preissenkung soll das Geschäft wachsen lassen. (Alibaba, Cloud Computing)