Teens with obesity lose 15% of body weight in trial of repurposed diabetes drug

The drug could be a useful new tool for treating childhood obesity.

Woman on a kg weight scale

Enlarge / Woman on a kg weight scale (credit: Getty | BSIP)

A repurposed Type 2 diabetes drug helped teens with obesity lose a significant amount of body weight,  lowered their risk factors for cardiovascular disease, and improved their weight-related quality of life over a 68-week clinical trial, researchers reported this week in the New England Journal of Medicine.

The drug is semaglutide (brand name Wegovy), which was first approved to treat Type 2 diabetes in 2017, but has since also proven useful for weight loss in adults who are obese or overweight. The drug works by mimicking a hormone called glucagon-like peptide-1 (GLP-1) that targets areas of the brain that regulate appetite and food intake, the Food and Drug Administration explained while approving its use for weight loss in adults.

The new data suggests that it may also substantially help teens struggling with obesity and overweight issues improve their health and outlook as they head into adulthood. One in five children and teens in the US has obesity, which can set children up for serious health conditions, including high blood pressure, high cholesterol, Type 2 diabetes, breathing problems, and joint problems, according to the Centers for Disease Control and Prevention.

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Lilbits: AMD’s first RDNA 3 GPUs, Netflix with ads, and goodnight Slingbox (maybe?)

AMD has unveiled the first graphics cards to feature the company’s new RDNA graphics architecture. The Radeon RX 7900 XT is a high-performance desktop GPU that will be available December 13th for $899, while the Radeon RX 7900 XTX is an even hig…

AMD has unveiled the first graphics cards to feature the company’s new RDNA graphics architecture. The Radeon RX 7900 XT is a high-performance desktop GPU that will be available December 13th for $899, while the Radeon RX 7900 XTX is an even higher performance version that will sell for $999. The company says RDNA 3’s […]

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Fresh chemical clues emerge for the unique sound of Stradivari violins

Another study found older, high-quality violins produce stronger combination tones

Violin against a red background.

Enlarge / A 1729 Stradivari known as the "Solomon, Ex-Lambert" on display at Christie's in New York in March 2007. (credit: Don Emmert/AFP/Getty Images)

Musicians and music aficionados alike have long savored the rich sound quality of the violins created by Antonio Stradivari, particularly at the dawn of the 18th century (the so-called "golden period"). Scientists have been equally fascinated by why Stradivari violins seem to sound so much better than modern instruments; it's been an active area of research for decades.

A recent paper published in the journal Analytical Chemistry reported that nanoscale imaging of two such instruments revealed a protein-based layer at the interface of the wood and the varnish, which may influence the wood's natural resonance, and hence the resulting sound. Meanwhile, another paper published in the Journal of the Acoustical Society of America showed that the better resonance of older violins produces stronger combination tones, which can also affect the perception of musical tones.

I've written extensively about this topic in the past, and you can read a handy summary of some of the research in this area to date here. Per my 2021 article, the (perceived) unique sound can't just be due to the instrument's geometry, although Stradivari's geometrical approach gave us the violin's signature shape. One hypothesis is that Stradivari may have used Alpine spruce that grew during a period of uncommonly cold weather, which caused the annual growth rings to be closer together, making the wood abnormally dense. Another popular theory has to do with the varnish: namely, that Stradivari used an ingenious cocktail of honey, egg whites, and gum arabic from sub-Saharan trees—or perhaps salts or other chemicals.

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At least 16 thousand people are still using Pebble smartwatches

Last week Google released a surprise update to the Pebble app for Android, allowing folks using the discontinued smartwatches to continue using them with smartphones devices running 64-bit only builds of Android (like the Google Pixel 7 series). Wonde…

Last week Google released a surprise update to the Pebble app for Android, allowing folks using the discontinued smartwatches to continue using them with smartphones devices running 64-bit only builds of Android (like the Google Pixel 7 series). Wondering how many people are still using Pebble watches in 2022? At least 16,000. That number comes […]

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OpenAI debuts DALL-E API so devs can integrate its AI artwork into their apps

OpenAI offers integrated AI image generation on a demand—for 2 cents an image.

Variations of

Enlarge / Variations of "a photo of a happy corgi puppy with fancy sunglasses on sitting and facing forward, studio light, longshot" generated by OpenAI's DALL-E. (credit: OpenAI)

On Thursday, OpenAI announced the introduction of an API for its DALL-E image synthesis model that will allow developers to easily integrate its AI image generation technology into their apps. DALL-E, currently available as a standalone commercial service, allows people to generate novel 1024x1024 images from text descriptions called "prompts." The generated images can vary in style from photorealistic to abstract—and many styles in between.

OpenAI's new API allows software developers to feed an image prompt and other parameters into OpenAI's DALL-E engine over the Internet. OpenAI then generates the image on its servers and returns the image for display in the requesting app. (An API is a programming interface that allows different programs to talk to each other.)

Usage of the API requires registration with OpenAI and a private API key that allows access to the DALL-E generator. Additionally, OpenAI levies a fee for each image generated depending on image resolution. Images that are 1024x1024 cost $0.02 an image, 512x512 images cost $0.018 per image, and 256x256 images cost $0.016 per image.

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AMD’s next-gen Radeon RX 7900 XTX and 7900 XT launch December 13, start at $999

RDNA 3 GPUs will use many chiplets to counter Nvidia’s gigantic RTX 4000 series.

AMD's Radeon RX 7900 XTX, floating in a red-tinged room somewhere.

Enlarge / AMD's Radeon RX 7900 XTX, floating in a red-tinged room somewhere. (credit: AMD)

AMD is gearing up to launch its next-generation Radeon RX 7000-series GPUs next month, and today the company shared more details about the cards' pricing, performance levels, and the new RDNA 3 GPU architecture that will power all of its graphics cards for the next couple of years.

The launch begins at the high end, with the Radeon RX 7900 XTX and RX 7900 XT. AMD will launch both of these GPUs on December 13, with the 7900 XTX starting at $999 and the XT starting at $899 (cards made by AMD’s partners will surely push these prices upward a bit). Both of these price tags undercut Nvidia’s RTX 4000 series, which starts at $1,599 for the top-tier GeForce RTX 4090 and $1,199 for the RTX 4080.

CPU Launch MSRP CUs Game clock RAM/bus width TBP
Radeon RX 7900 XTX $999 96 (RDNA 3) 2300 MHz 24GB GDDR6 (384-bit) 355 W
Radeon RX 6950 XT $1,099 80 (RDNA 2) 2100 MHz 16GB GDDR6 (256-bit) 335 W
Radeon RX 7900 XT $899 84 (RDNA 3) 2000 MHz 20GB GDDR6 (320-bit) 300 W
Radeon RX 6800 XT $649 72 (RDNA 2) 2015 MHz 16GB GDDR6 (256-bit) 300 W

Nvidia had planned to field a 12GB version of the RTX 4080 in this price range, but a consumer backlash to its potentially confusing branding and lower performance level prompted Nvidia to "unlaunch" the card, with no word on when it will be re-introduced, what it will be called, or what it will cost. The 16GB version of the 4080 launches November 16, beating AMD's new GPUs to market by around a month.

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MPA: Mandatory Release Windows Could Exacerbate Piracy

Over recent decades, theatrical movie release windows have shrunk significantly around the world. In France, however, movie fans still have to wait more than a year before they can stream the latest blockbusters. The MPA flags this mandatory release window as a potential trade barrier, with the potential make piracy even worse.

From: TF, for the latest news on copyright battles, piracy and more.

broken windowThe Motion Picture Association (MPA) represents several of the world’s largest movie industry companies.

Traditionally its members were restricted to top Hollywood studios such as Disney and Warner Bros, but three years ago streaming giant Netflix joined the exclusive club.

The newcomer hasn’t changed the MPA’s main goal of protecting its members’ content from piracy. The MPA is the driving force behind the Alliance for Creativity and Entertainment which tackles copyright infringement globally on behalf of dozens of major rightsholders, Netflix included.

Foreign Trade Barriers

Aside from enforcement, the MPA is also heavily involved in lobbying efforts. This week it sent an overview of global copyright-related challenges to the US Trade Representative (USTR), as input for the yearly report on foreign trade barriers.

As usual, the comments detail piracy problems and challenges in countries around the globe. They include concerns over lacking anti-camcording legislation, weak anti-piracy enforcement, as well as general shortcomings in overseas copyright laws.

The general tendency of these comments is that ‘more’ should be done to address the piracy problem. However, when looking over this year’s report, we noticed an interesting observation, suggesting that less can sometimes be more.

France’s Release Windows

As reported a few months ago, France has a “media chronology” law that grants an exclusive release window to movie theaters. This also applies to streaming services such as Netflix, Amazon Prime, and Disney+.

The theatrical release window was reduced from three years to 15-17 months earlier this year. While that’s a step in the right direction, streaming services would like the window to be reduced even further.

According to the MPA, these windows could be seen as a trade barrier that, as suggested, might make piracy an even bigger problem.

“The media chronology was last updated in January 2022. However, several international and local stakeholders have argued that the chronology lacks flexibility, that the mandated release windows are too long, and that such windows exacerbate piracy,” the MPA writes.

release windows

Sensitive Issue

The MPA points to “stakeholders” and doesn’t take a strong position itself. The windowing issue is highly sensitive as many movie theater owners believe that shorter windows will hurt box office revenues.

When movie companies began to experiment with simultaneous streaming and theatrical releases during the COVID pandemic, theater owners sounded the alarm bell. According to the movie theater industry group NATO, exclusive release periods are vital to the survival and success of the industry.

The MPA is more reserved and doesn’t believe that the two revenue streams are in competition. This could also explain why the group decided to highlight the issue in a trade barriers report.

Italy Too

Interestingly, the discussion doesn’t end with France. Italy also considered a 90-day mandatory release window for all theatrical films this year. This also has the MPA worried, even though piracy isn’t mentioned directly there.

Instead, the Hollywood group is worried about the marketing issues these windows could present.

“MPA is concerned about the impact of such an extension on a broad scale, as this mandatory window would have serious repercussions on producers’ ability to adequately market their works,” the movie group notes.

The marketing problem could also have piracy repercussions, of course. If a film’s digital release is widely promoted throughout the world, Italians may be more eager to pirate it if no legal options are available to them.

All-in-all, the MPA’s release window comments, no matter how small, are noteworthy. For decades consumers have called for shorter windows and it appears that several movie industry stakeholders are now in the same camp.

The full overview of the MPA’s trade barrier comments to the US Trade Representative is available here (pdf).

From: TF, for the latest news on copyright battles, piracy and more.

In-car VR arrives for new Audis courtesy of Holoride

It’s not nearly as vomit-inducing as you’d think.

In-car VR that adapts the content to the car's motion through space is now a thing, thanks to Holoride.

Enlarge / In-car VR that adapts the content to the car's motion through space is now a thing, thanks to Holoride. (credit: Holoride)

Virtual reality is coming to the passenger seat near you, at least as long as you own an Audi vehicle with the brand's most current operating system, anyway. The Audi spinoff, Holoride, announced this week that it will begin offering the Pioneer Pack for just under $700, which includes an HTC VIVE Flow headset, an 8BitDo Pro 2 Gamepad, and a year-long subscription to the Holoride platform, for those who own a 2023 Audi or newer (with the MIB 3 system). I got a quick taste of the strange in-car VR experience around my neighborhood in Los Angeles and, in spite of a tendency toward motion sickness, managed to play a video game and watch a little bit of Netflix before tapping out.

Like my cohort, who tried the Holoride experience during CES in 2019, I am not a VR aficionado, though I am fully on board (and regularly use) AR glasses for work; the Nreal AR glasses I use have made a world of difference when I have to bang out 10,000 words in a single day, resulting in a lot less computer fatigue and repetitive motion pain. So, when the engineers from Holoride strapped the HTC Vive Flow headset to my face, it wasn't an unfamiliar sensation, but it was far more visually restrictive than I'm comfortable with, especially in the back seat of a moving vehicle. The team handed me a familiar game controller, and we were off, in spite of my nerves about the possibility of getting ill in mere minutes in the back seat of the BMW X5 that the team was using for demo purposes.

The visuals

When you first strap in, you adjust the eyepieces of the HTC Vive Flow headset the same way you would adjust binocular diopters. I don't wear glasses except when I'm reading or working at the computer but did have a hard time finding a reasonably clear image in the glasses. I don't wear my glasses when I'm wearing the Nreals, but in retrospect, I probably should have used them under the relatively lightweight Holoride headset since the images never really got super clear.

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Steam on Chromebooks reaches beta status and adds support for more hardware

Google is bringing support for Steam gaming to more Chromebook users staring with the rollout of ChromeOS 108. When Steam for Chromebooks first launched earlier this year, it was only available for a handful of devices and users had to be willing to r…

Google is bringing support for Steam gaming to more Chromebook users staring with the rollout of ChromeOS 108. When Steam for Chromebooks first launched earlier this year, it was only available for a handful of devices and users had to be willing to run Alpha software on potentially unstable Dev Channel builds of ChromeOS. But […]

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