For T-cells, omicron is nothing unusual

T-cell response from earlier infection or vaccination is down, but not by much.

Image of two spherical objects with a set of processes between them.

Enlarge / False-color image of a T-cell (orange) latching on to a cell in preparation for killing it. (credit: Getty Images)

From the start, the omicron variant had people worried because its version of the spike protein carried mutations in many of the sites that are recognized by antibodies. This meant that antibodies generated to combat earlier variants like delta were less likely to recognize the newcomer. These fears have played out in the form of lowered immunity to omicron, along with the failure of some antibody-based therapies.

But all those fears were focused on the immune system's antibody response; the immune system also produces T-cells that recognize the virus, and it's not clear how omicron affected their response. Based on two recently published papers, the answer is "not much at all," which could help explain why the vaccines continue to protect from severe disease.

Those other cells

The T-cell-based immune response works very differently from that of antibody-producing cells. It relies on the fact that all cells chop up a small fraction of the proteins they make. Specialized proteins then grab on to some of the resulting protein fragments and display them on the cell's surface. Once on the surface, they can be recognized by a receptor on the surface of T-cells.

Read 12 remaining paragraphs | Comments

Producer: Star Trek: Strange New Worlds will connect to a famous wrathful villain

Prequel series on Paramount+ will also feature a return to episodic storytelling.

Promotional image for upcoming Star Trek series.

Enlarge (credit: Paramount+)

The Star Trek franchise continues to expand on Paramount+ with the upcoming prequel series Star Trek: Strange New Worlds, which debuts in May. The show's executive producers and key cast members were on hand this week for a virtual panel discussion as part of the 2022 Winter Television Critics Association (TCA) meeting. In addition to unveiling the poster art, the panel revealed that one of the characters will have an (as yet unspecified) connection to one of the franchise's most famous wrathful villains.

As we've written previously, one of the highlights of Star Trek: Discovery's second season was the appearance of classic Original Series (TOS) characters Capt. Christopher Pike (Anson Mount), Number One (Rebecca Romijn), and Spock (Ethan Peck). The actors reprise their roles in the new spinoff series Star Trek: Strange New Worlds, created by Alex Kurtzman, Akiva Goldsman, and Jenny Lumet. It's a prequel to TOS, as Pike and his crew navigate the USS Enterprise through the galaxy, exploring new worlds along the way.

Paramount+ hasn't let many details leak about the new series. We didn't even get an official teaser during Star Trek Day last year, although there was a video introducing all the main cast members. In addition to Mount, Romijn, and Peck, Babs Olusanmokun plays Dr. M'Benga; Celia Rose Gooding has the unenviable task of filling Nichelle Nichols' shoes as Cadet Nyota Uhura; Jess Bush plays Nurse Christine Chapel; Melissa Navai plays Lieutenant Erica Ortegas; Bruce Orak plays an Aenar named Hemmer; and Christina Chong plays La'An Noonien-Singh. The latter character is apparently related to the classic revenge-obsessed Star Trek villain Khan, according to Goldsman, although he didn't offer any specifics about what that connection might be.

Read 11 remaining paragraphs | Comments

iTunes DRM Removal Could Come Back to Haunt Record Labels in Piracy Liability Lawsuit

In 2009, the major record labels decided to remove DRM from music in the iTunes store. More than a decade has passed since but the issue could now make a comeback in a piracy liability lawsuit. Internet provider RCN plans to use it as a defense, while the labels claim that the DRM issue is old and irrelevant.

From: TF, for the latest news on copyright battles, piracy and more.

no-drmIn the late 2000s, music fans were delighted by the news that record labels and Apple had agreed to remove all DRM from music files downloaded through the iTunes Store.

The music industry had initially insisted on strong copy protection to make it harder for music pirates to share these files. However, legitimate consumers were inconvenienced by these measures too.

The removal was a breakthrough for anti-DRM advocates and a big step for the music industry, which has become more streaming-focused since. However, well over a decade after the iTunes DRM removal decision, the issue is being revisited in a high-profile piracy case.

Record Labels vs. RCN

Three years ago, several major music labels including Arista Records, Sony Music Entertainment, Universal Music, and Warner Records, filed a lawsuit against U.S. Internet provider RCN. The music companies accused the company of failing to take action against subscribers who were accused of repeat copyright infringements.

There are a few of these piracy liability lawsuits ongoing at the moment. These are not trivial legal battles as there are hundreds of millions of dollars in damages at stake. Therefore, RCN is using all available options to fight back.

After attempts to dismiss the lawsuit and dispute the piracy evidence failed, the Internet provider is now exploring other options to aid its defense.

ISP Zooms in on DRM Removal

To this end, the company would like to know more about the decision to remove DRM from iTunes downloads. Specifically, it asked the music companies during discovery to disclose who were involved in the DRM decision.

“[i]dentify all persons who participated in Plaintiffs’ decision in or around 2009 to remove Digital Rights Management (‘DRM’) from sound recordings sold through the iTunes Store,” the request reads.

The ISP notes that DRM was supposed to make it harder for people to share iTunes tracks illegally using BitTorrent. So, in theory, removing this protection could have increased the piracy numbers.

“It is certainly reasonable to infer that this decision—along with Plaintiffs’ continuing decision not to re-impose the use of DRM—has affected the frequency with which Plaintiffs’ music is shared over peer-to-peer networks,” RCN writes.

RCN previously asked the music companies for information about its use of DRM but the labels replied that they couldn’t find any matching documents. So, talking directly to the people who were involved in the DRM removal decision is their only option.

‘DRM is Irrelevant’

The ISP suggests that the labels themselves could have done more to stop piracy and that removing DRM was counterproductive. However, the music companies don’t want to share any names and refuse to point out who was involved in the DRM discussions.

In a letter to the New Jersey federal court, the labels point out that the entire DRM issue is irrelevant for this case. It was taken in 2009, which is years before the alleged infringements at the center of the lawsuit took place.

“RCN is seeking information on measures taken (or not taken) in 2009, two years before the first of the infringements identified by Rightscorp’s notices and seven years before Plaintiffs knew about any of those infringements.

“Thus, any alleged decisions Plaintiffs made regarding DRM are necessarily limited to pre-injury conduct that is irrelevant to RCN’s failure-to-mitigate defense,” the labels add.

Memories Have Faded…

Aside from the judicial arguments, the music companies also point out that, after thirteen years, it might not even be possible to find out who was involved. And even if they do, the key players might not accurately recall what happened at the time.

“At this point, it may prove difficult to identify relevant individuals. Further, the identification of such persons is of minimal value in that their memories of this issue will undoubtedly have faded,” the companies argue.

It is now up to the court to decide whether the labels must comply with the discovery request or not. If the removal of DRM indeed resulted in more piracy, it doesn’t change how RCN responded to it. However, the ISP does believe that it’s relevant for the potential damages that are claimed.

A copy of the music companies’ request to sustain their objections to the DRM removal interrogatory is available here (pdf)

From: TF, for the latest news on copyright battles, piracy and more.

Lilbits: Dragonbox Pyra, ScummVM, and LibreOffice updates and Google’s Pixel 6 is a hit (by Pixel standards)

The DragonBox Pyra is a handheld computer designed to run Linux-based software and which includes a QWERTY keyboard and built-in game controllers allowing you to use it for work or play. At least that’s the idea… but getting your hands on one has been challenging. The Pyra has been in development for years and went […]

The post Lilbits: Dragonbox Pyra, ScummVM, and LibreOffice updates and Google’s Pixel 6 is a hit (by Pixel standards) appeared first on Liliputing.

The DragonBox Pyra is a handheld computer designed to run Linux-based software and which includes a QWERTY keyboard and built-in game controllers allowing you to use it for work or play. At least that’s the idea… but getting your hands on one has been challenging.

The Pyra has been in development for years and went up for pre-order in 2016. But it only began shipping to customers in late 2020 and since then only around 200 units have been shipped. In a 2021 year-end update, project leader Michael Mrozek said a key reason for that was a case manufacturing defect that meant each unit had to be assembled by hand to make sure everything worked properly. But things could pick up a bit in 2022.

Lucas Wagner / YouTube

The next batch of cases shouldn’t suffer from the same issues, which means that it should become quicker to assemble and ship units moving forward. But this is still a niche device aimed at enthusiasts: It’s rather chunky by modern standards and has a TI OMAP 5 ARM Cortex-A15 dual-core processor that was introduced a decade ago.

With prices starting at 595 Euros (about $670 US), the Pyra certainly isn’t a Steam Deck killer. But it is unlike anything else currently on the market as a hacker-friendly handheld computer designed to run free and open source software and sporting features like dual SDXC card readers, a removable battery, and even a removable CPU board that could theoretically pave the way for upgrading the processor without replacing the whole computer (although given the glacial pace pace of development, I wouldn’t hold my breath waiting for CPU upgrades to become available anytime soon).

Here’s a roundup of recent tech news from around the web.

DragonBox Pyra handheld PC update [pyra-handheld forum]

The first 100-200 Dragonbox Pyra handheld Linux gaming PCs shipped in 2021, but they had to be hand-assembled due to a case manufacturing defect. The issue should be resolved now, which could allow production and distribution to ramp up in 2022.

Google’s Pixel phones had their best quarter ever [Engadget]

Google’s Pixel phones get a lot of attention from press and enthusiasts, but they still have a pretty tiny market share. With that in mind, it’s worth noting that Google says it just hit a “quarterly sales record” for Pixel phones thanks to the popularity of the Pixel 6 with both consumers and wireless carriers. But since we don’t know exactly how many phones Google sold, the fact that the company hit a new record doesn’t really tell us very much. 

Porting Windows 11 to the Microsoft Surface Duo dual-screen smartphone [@gus33000]

The Microsoft Surface Duo is a dual-screen smartphone that ships with Android. But developer Gustave Monce has begun porting Windows 11 to run on the device. So far the installer is up and running.

LogMeIn becomes GoTo [LogMeIn]

LogMeIn is rebranding itself as GoTo (the company also owns GoToMeeting as well as password manager LastPass, although it announced plans in December to spin off LastPass).

ScummVM begins testing Hypno game engine [ScummVM]

ScummVM, which lets you run hundreds of classic PC games on modern computers, is adding a “Hypno” engine for playing 90s games from Hypnotix. The first supported game is now ready for testing: Marvel Comics Spider Man: The Sinister Six.

LibreOffice 7.3 release notes [LibreOffice]

LibreOffice 7.3 released with new features and improvements including better performance when opening large DOCX and XLSX files, improved import/export filters, support for hyperlinks attached to shapes, and much more.

Steam Deck Review coming soon [The Phawx]

Most Steam Deck reviews you’re likely to see later this month will come from folks who are comparing it to larger gaming PCs and/or handheld consoles (like the Switch). But The Phawx has tested most handheld gaming PCs released in the last 5 years. Here’s a teaser video where he explains what he’ll cover in the upcoming review. 

Keep up on the latest headlines by following Liliputing on Twitter and Facebook and follow @LinuxSmartphone on Twitter and Facebook for the latest news on open source mobile phones.

The post Lilbits: Dragonbox Pyra, ScummVM, and LibreOffice updates and Google’s Pixel 6 is a hit (by Pixel standards) appeared first on Liliputing.

Google Workspace to strip privacy control from admins, re-enable tracking

Users that shut off “Web & App Activity” will have data retention turned back on.

The word

Enlarge (credit: Aurich Lawson / Getty Images)

Starting on March 29, Google is changing its infamous "Web & App Activity" controls for paid users of Google Workspace. That setting is now being split up into two settings, one still called "Web & App Activity" and another called "Search history." The big news is that Google is taking advantage of this settings split to re-enable some tracking features even if users have previously opted out.

Google has started emailing Workspace administrators about the change (thanks, Hacker News), and a support page sort of details what's going on. Both the email and support page are incredibly confusing—even Google's own employees have a hard time parsing Google's privacy controls—but we're going to try to get through this together.

The support page begins, "Starting March 29, 2022, the Web & App Activity Admin console setting is going away." "Web & App Activity" is one of the two main Google privacy settings (along with "Location History") that saves everything you do on your Google account. You might remember these settings from several lawsuits about how confusing and poorly labeled they were. Leaving these settings on means that features like autocomplete work better, but it also means Google gets to keep all your activity.

Read 8 remaining paragraphs | Comments

Daily Deals (2-02-2022)

Amazon is selling refurbished Fire HD 8 tablets for $40 and up and refurbished Fire HD 8 Plus tablets for $50 and up. Those are pretty good prices for either model, but the Plus model has 50% more RAM and support for wireless charging. You can find more details in Liliputing’s Fire Tablet spec comparison. […]

The post Daily Deals (2-02-2022) appeared first on Liliputing.

Amazon is selling refurbished Fire HD 8 tablets for $40 and up and refurbished Fire HD 8 Plus tablets for $50 and up. Those are pretty good prices for either model, but the Plus model has 50% more RAM and support for wireless charging. You can find more details in Liliputing’s Fire Tablet spec comparison.

Meanwhile, Lenovo’s offering hard-to-beat pricing on a ThinkBook 13s laptop with 16GB of RAM, 512GB of storage, and an AMD Ryzen 5 5600U processor. You can pick one up from the company’s eBay store for just $650 (which is $220 less than the same laptop costs if you buy it from Lenovo.com).

Lenovo ThinkBook 13s

Here are some of the day’s best deals.

Laptops

Tablets

Smart Displays

Storage

Other

The post Daily Deals (2-02-2022) appeared first on Liliputing.

Windows PCs prioritized over Chromebooks in components shortage

Chromebooks are getting increasingly popular, though.

Windows PCs prioritized over Chromebooks in components shortage

Enlarge (credit: Google)

In a tech world still hindered by component shortages, choices have to be made. And in the world of laptops, it seems that choice is Windows-based devices over those running Chrome OS.

IDC on Monday released early data from its latest Worldwide Quarterly Personal Computing Device Tracker. It pointed to a sharp 63.6 percent decline in Chromebook shipments, which the IDC defines as "shipments to distribution channels or end users, in Q4 2021 (4.8 million shipments) compared to Q4 2020 with (13.1 million shipments)."

In addition to market saturation, supply issues also hurt Chromebook shipments, as the industry still struggles with a deficit of PC components, from CPUs to integrated circuits for Wi-Fi modules and power management.

Read 7 remaining paragraphs | Comments

Report: NSO offered US firm “bags of cash” for help spying on cellphone users

“We drop bags of cash at your office”: NSO allegedly sought access to SS7 network.

A bag of money surrounded by a pile of money.

Enlarge (credit: Getty Images | spxChrome)

A whistleblower has accused Pegasus spyware-maker NSO Group of offering "bags of cash" to security company Mobileum in exchange for access to cellular networks in 2017. According to reports yesterday by The Guardian and The Washington Post, former Mobileum VP Gary Miller made his allegations in a complaint to the US Department of Justice and in an interview with news organizations that are part of the "Pegasus Project" consortium.

Miller alleged that during the Mobileum/NSO Group meeting, "a member of his own company's leadership at Mobileum asked what NSO believed the 'business model' was of working with Mobileum, since Mobileum did not sell access to the global signalling networks as a product," The Guardian wrote. "According to Miller, and a written disclosure he later made to federal authorities, the response allegedly made by [NSO co-founder Omri] Lavie was 'we drop bags of cash at your office.'"

NSO Group, an Israeli company that was recently blacklisted by the US government, was allegedly seeking access to the SS7 network. Mobileum's various security products include an SS7 firewall, and the company's website warns that "modestly priced access to the SS7 network is now available to hackers on a modest budget."

Read 11 remaining paragraphs | Comments

NASA delays SLS rocket rollout, says launch date is TBD

“We’d like to hold off and talk about that after we get to the wet dress.”

The Space Launch System main engines are seen in High Bay 3 of the Vehicle Assembly Building at NASA’s Kennedy Space Center on Jan. 10, 2022.

Enlarge / The Space Launch System main engines are seen in High Bay 3 of the Vehicle Assembly Building at NASA’s Kennedy Space Center on Jan. 10, 2022. (credit: NASA)

NASA officials on Wednesday said the agency would conduct an initial rollout of the massive Space Launch System rocket sometime in March, a multi-week delay attributed to "close-out" tasks that must be completed on the vehicle.

Until this week, NASA had been publicly targeting a February 15 rollout date, when a mobile tower would ferry the SLS rocket from the Vehicle Assembly Building to its launch site at Kennedy Space Center in Florida. Tom Whitmeyer, deputy associate administrator for exploration systems development at NASA Headquarters, said the agency is now targeting "mid-March" for the rollout, but he did not want to set a specific date.

Whitmeyer and other officials on a teleconference with reporters said they wanted to let the teams of NASA employees and contractors in Florida complete their work meticulously rather than being rushed.

Read 9 remaining paragraphs | Comments

EU plans to label natural gas and nuclear power plants “sustainable”

Critics pan the proposal but face uphill battle to kill the measure.

EU plans to label natural gas and nuclear power plants “sustainable”

Enlarge (credit: iStock)

The European Union says it wants to “prevent greenwashing” among investors, but a new proposal may end up encouraging the behavior it wants to banish.

The European Commission put forward a plan today that defines what counts as a “sustainable investment,” something that’s all but required to manage a transition to clean energy. But to the chagrin of several EU countries, environmental groups, and asset managers, the proposal would allow both natural gas and nuclear to qualify as “contributing substantially to climate change mitigation.”

The split-the-baby approach came about because some countries, including Germany and Poland, lobbied for the inclusion of natural gas, while others, notably France, lobbied for nuclear power. Germany, which is in the process of shuttering its nuclear power plants, remains heavily dependent on coal and has been boosting its use of natural gas to “transition” away from coal. France, on the other hand, uses relatively little natural gas and gets nearly all of its electricity from nuclear power plants.

Read 9 remaining paragraphs | Comments