Holding a mirror to life’s key molecules

Life only works with chemicals that have the right orientations—but chemists don’t.

Illustration of chemical molecules superimposed over sketched hands.

Enlarge / The left- and right-handed forms of an amino acid. Every living thing uses the left-handed form exclusively. (credit: Wikimedia Commons)

The central dogma of molecular biology holds that DNA gets transcribed into RNA, which then gets translated into proteins. Of course, there are exceptions—some viruses, like coronaviruses, forego DNA altogether and encode their genetic information in RNA genomes. Other viruses, like HIV, have RNA genomes that must be copied into DNA and then transcribed back into RNA before being made into proteins. But as a general rule, "DNA to RNA to protein" describes how information moves within cells.

A unique property of biological molecules is that they have handedness. Naturally occurring molecules occur in roughly equal mixtures of left- and right-handed varieties. This means that molecules can have identical atoms and shapes but cannot be superimposed one upon the other. Instead, they are mirror images of each other, like our right and left hands.

(This can be difficult to envision, which is why pre-meds taking organic chemistry in college spend so much time playing with those ball-and-stick molecular models.)

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Record Labels Sue Charter Again For Failing to Disconnect Pirating Subscribers

A group of major music publishing companies has filed another copyright infringement lawsuit against Charter Communications. The companies argue that, despite repeated warnings, the ISP still fails to take action against pirating subscribers. The new lawsuit covers more recent infringements that started in 2018.

From: TF, for the latest news on copyright battles, piracy and more.

cassette tape pirate musicIn March of 2019, several major music companies sued Charter Communications, one of the largest Internet providers in the US with 22 million subscribers.

Helped by the RIAA, Capitol Records, Warner Bros, Sony Music, and others accused Charter of deliberately turning a blind eye to its pirating subscribers.

Among other things, they argued that the ISP failed to terminate or otherwise take meaningful action against the accounts of repeat infringers, even though it was well aware of them. As such, the music companies said Charter is liable for both contributory infringement and vicarious liability.

Charter disagreed and filed a motion to dismiss the case. In addition, it countersued the record labels for sending false DMCA takedown notices. Both of these defensive moves failed and the matter is now scheduled to go to trial.

Charter is Sued Again

With hundreds of millions of dollars in potential damages, the stakes are high. And they’re about to get even higher, as the music companies have just filed another copyright infringement lawsuit against Charter.

According to the music companies, which include Capitol Records, EMI, Sony Music and Universal Music, the lawsuit hasn’t resulted in the desired policy change with regard to pirating subscribers. As such, they have filed yet another lawsuit at a federal court in Colorado.

“Charter has insisted on doing nothing—despite receiving thousands of notices that detailed the illegal activity of its subscribers, despite its clear legal obligation to address the widespread, illegal downloading of copyrighted works on its Internet services, and despite being sued previously by Plaintiffs for similar conduct,” the complaint reads.

Lawsuit Covers Recent Claims

The lawsuit essentially accuses Charter of the same wrongdoing. While that seems pointless at first, there is an important distinction. The initial case only covered copyright infringements up to 2016, while the new complaint covers repeat infringements from 2018 onwards.

The music companies explain that they formally warned Charter about the first batch of infringement claims in March and April 2016. Their goal was to motivate the ISP to take action against pirating subscribers, but not much changed.

Even after the first lawsuit was filed, pirating subscribers were allegedly able to continue their infringing activity.

“Plaintiffs believed—or at least hoped—that in response to these notices, Charter would alter its conduct and take meaningful steps to address ongoing infringement by its subscribers. Unfortunately, that did not happen,” the music companies write.

“Instead, Charter persisted in contributing to and profiting from its subscribers’ infringement of Plaintiffs’ copyrights through Charter’s network, even after receiving Plaintiffs’ March and April 2016 notices of claims and, remarkably, even after Plaintiffs filed the 2019 Lawsuit.”

‘Safe Haven for Pirates’

The music companies say they sent more than 150,000 additional infringement notices to Charter during the latest claim period, without the desired result.

The ISP says it takes action against repeat infringers, but the music companies don’t believe much has changed. This alleged failure to take meaningful anti-piracy action made Charter a safe haven for copyright infringers, according to the plaintiffs, which say that the ISP prioritizes profits over its legal responsibility.

“Charter’s motivation for refusing to terminate or suspend the accounts of blatant infringing subscribers is simple: it valued corporate profits over its legal responsibilities. Charter did not want to lose subscriber revenue by terminating accounts of infringing subscribers.”

Similar to the earlier lawsuit, which is still pending, the copyright holders ask to be compensated for the damages they suffered. With thousands of works at stake, these damages could be as high as hundreds of millions of dollars.

It’s not entirely clear why the music companies want to pursue two similar but separate lawsuits. It is possible, however, that this is a tactical move and that the cases will be merged in the future.

A copy of the new complaint against Charter Communications, filed at the U.S. District Court for the District of Colorado, is available here (pdf)

From: TF, for the latest news on copyright battles, piracy and more.

Y: The Last Man TV series gets premiere trailer ahead of Sept. 13 Hulu launch

Soon, we’ll learn whether live-action Hulu series lives up to Eisner-winning comics.

A TV series based on Y: The Last Man, the award-winning Vertigo comic series about a sex-specific apocalypse, has always seemed inevitable, but ever since the comic series wrapped in 2008, plans for a live-action adaptation have lingered in apparent development hell. That all changes next month, when a TV series finally launches on Hulu. The news came in the form of a trailer that shows off the series' stars while explaining its peculiar twist on a society-crushing disease.

The original comics, written by former Lost writer/producer Brian K. Vaughan (also involved with beloved comic series like Saga and Paper Girls), revolved around the simultaneous death of everything on Earth with a Y chromosome, humans and animals alike. Thursday's new trailer recaps the same premise by focusing on the president of the United States succumbing to a bloody collapse, followed by apparently every other man on the planet... save one.

That man, Yorick Brown (played by Ben Schnetzer), begins making his way across a decimated United States, and this TV version matches the comics by including his pet monkey named Ampersand (who also has a Y chromosome). Meanwhile, his mother, Senator Jennifer Brown (played by Diane Lane), apparently assumes control as president of the United States. That's a twist on the original comics, which had Yorick's mother in Congress but not necessarily promoted to the top of the pecking order.

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New Google Nest Cams can record video without a monthly subscription

Google hopes less restrictive subscription requirements will entice more buyers.

Google is introducing updates to the Nest camera line with a new version of the Google Nest Doorbell and several new versions of the Google Nest Cam. The company is also toning down the Nest Cam's restrictive business model, which previously has all but required paying a monthly subscription fee to get a useful camera.

We'll get to the new models in a minute, but the biggest news is that Google is making the cameras more useful without a monthly subscription. Previously, core camera features like recording video were locked behind a $6-$12 monthly subscription plan called "Nest Aware," but the new cameras can now record local video. You only get three hours' worth of "events" (motion detection, as opposed to 24/7 video), but it's a start. Google has also moved activity zones and some image recognition features from the cloud-based pay-per-month service to on-device processing, so they work without a subscription, too.

If you still want to pay for the "Nest Aware" subscription, it comes in two tiers. There's the $6 "Nest Aware," which gives you 30 days of "event" video history and facial recognition. The free tier can detect and alert you about people, animals, and vehicles, but the subscription adds facial recognition for "familiar faces" so Nest can tell if a loved one or stranger is at the door and alert you accordingly. The $12-per-month tier is "Nest Aware Plus," which provides 60 days of event video history and 10 days of 24/7 video history if you have a wired (not battery-powered) Google Nest Cam (the doorbell can't record continuous video).

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Lilbits: 3dfx is back (but not really) and more JingPad A1 Linux tablet performance notes

Over the past week or so, a new Twitter account has been teasing the return of a classic name in computer graphics. But now that the new 3dfx has made it official, it’s clear that the new company has very little of the DNA of its predecessor oth…

Over the past week or so, a new Twitter account has been teasing the return of a classic name in computer graphics. But now that the new 3dfx has made it official, it’s clear that the new company has very little of the DNA of its predecessor other than rights to use the 3dfx name […]

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The hydrogen economy is about to get weird

Companies may be investing in production capacity that will outpace demand.

Image of a blue light rail vehicle.

Enlarge / A Coradia iLint hydrogen fuel-cell powered prototype railway train, manufactured by Alstom SA, travels in Salzgitter, Germany. (credit: Bloomberg/Getty Images)

If you were paying attention at the start of this century, you might remember the phrase "hydrogen economy," which was shorthand for George W. Bush's single, abortive attempt to take climate change seriously. At the time, hydrogen was supposed to be a fuel for vehicular transport, an idea that still hasn't really caught on.

But hydrogen appears to be enjoying a revival of sorts, appearing in the climate plans of nations like the UK and Netherlands. The US government is investing in research on ways to produce hydrogen more cheaply. Are there reasons to think hydrogen power might be for real this time?

A new report by research service BloombergNEF suggests that hydrogen is set for growth—but not in transport. And the growth has some aspects that don't actually make sense given the current economics.

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Apple plans to scan US iPhones for child abuse imagery

Security researchers raise alarm over potential surveillance of personal devices.

Five iPhones on a table

Enlarge / The 2020 iPhone lineup. From left to right: iPhone 12 Pro Max, iPhone 12 Pro, iPhone 12, iPhone SE, and iPhone 12 mini. (credit: Samuel Axon)

Apple intends to install software on American iPhones to scan for child abuse imagery, according to people briefed on its plans, raising alarm among security researchers who warn that it could open the door to surveillance of millions of people’s personal devices.

Apple detailed its proposed system—known as “neuralMatch”—to some US academics earlier this week, according to two security researchers briefed on the virtual meeting. The plans could be publicized more widely as soon as this week, they said.

The automated system would proactively alert a team of human reviewers if it believes illegal imagery is detected, who would then contact law enforcement if the material can be verified. The scheme will initially roll out only in the US.

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Squirrels show off killer parkour moves as they leap from branch to branch

Pushing off vertical surface helped squirrels adjust their speed for a better landing.

High-speed video of squirrels executing amazing leaps in pursuit of peanuts captures the animals' innovative solutions to reaching their goal. Video courtesy of Roxanne Makasdjian and Jeremy Snowden, University of California, Berkeley.

The campus of the University of California, Berkeley, boasts three known wild populations of fox squirrels, who spend their days cavorting among the tree branches and foraging for sustenance. They've also now made a contribution to science, thanks to a series of experiments by UC-Berkeley researchers aimed at assessing how squirrels figure out whether or not to leap from one given tree branch to another.

In the process, the team caught several squirrels resorting to innovative moves, reminiscent of parkour, to execute especially tricky maneuvers, re-orienting their bodies to push off a vertical surface to ensure a smooth, safe landing. The team described its findings in a new paper published in the journal Science.

Squirrels are masters at navigating through the treetops, jumping from branch to branch without falling. "As a model organism to understand the biological limits of balance and agility, I would argue that squirrels are second to none," said co-author Nathaniel Hunt, a former UC-Berkeley graduate student who is now researching biomechanics at the University of Nebraska, Omaha. "If we try to understand how squirrels do this, then we may discover general principles of high performance locomotion in the canopy and other complex terrains that apply to the movements of other animals and robots."

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Blue Origin’s powerful BE-4 engine is more than four years late—here’s why

“This is a success oriented approach, but it could definitely backfire.”

Image of a BE-4 rocket engine on a test stand in West Texas.

Enlarge / Image of a BE-4 rocket engine on a test stand in West Texas. (credit: Blue Origin)

After more than four years of frustrating delays, Blue Origin is finally making significant progress toward completing development of its powerful BE-4 rocket engine. At present, engineers and technicians with the company are assembling the first two flight engines at Blue Origin's main factory in Kent, Washington.

The company aspires to deliver these two flight engines to United Launch Alliance before the end of this year, although that increasingly appears to be a "stretch" goal. Delivery may slip into early 2022. And in order to make this deadline, Blue Origin plans to take the somewhat risky step of shipping the engines to its customer before completing full qualification testing.

This delivery has been a long time coming. United Launch Alliance, or ULA, first agreed to buy the engines from Blue Origin back in 2014. It was a bold bet by ULA, a blueblood in space launch, on a new entrant to the market. But with the BE-4 engine, Blue Origin founder Jeff Bezos was promising a relatively low-cost, high performing engine with a power output comparable to a Space Shuttle main engine. At the time of this initial agreement, Blue Origin said the BE-4 would be "ready for flight" by 2017.

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Daily Deals (8-05-2021)

Microsoft’s Surface Duo dual-screen Android phone sold for $1400 when it debuted last year. Today you can pick up a model with 64GB of storage for $389 or a 128GB version for $470. Or you could just pick up a Pixel 4 for $379 if you’re loo…

Microsoft’s Surface Duo dual-screen Android phone sold for $1400 when it debuted last year. Today you can pick up a model with 64GB of storage for $389 or a 128GB version for $470. Or you could just pick up a Pixel 4 for $379 if you’re looking for an affordable phone that you plan to […]

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