Making fuel molecules in yeast: Much harder than you’d imagine

Systems-level engineering of a living thing is remarkably complicated.

Images of white, fuzzy dots on a blue background.

Enlarge / Colonies of genetically modified yeast. (credit: Conor Lawless)

A little while ago, we covered the idea of using photovoltaic materials to drive enzymatic reactions in order to produce specific chemicals. The concept is being considered mostly because doing the same reaction in a cell is often horribly inefficient because everything else in the cell is trying to regulate the enzymes, trying to use the products, trying to convert the byproducts into something toxic, or up to something even more annoying. But in many cases, these reactions rely on chemicals that are only made by cells, leaving some researchers to suspect it still might be easier to use living things in the end.

A new paper in Nature Catalysis may support or contradict this argument, depending on your perspective. In the end, the authors of the new paper re-engineer standard brewer's yeast to produce molecules that can be used as fuel for internal combustion engines. The full catalog of changes they have to make is a bit mind-numbing and most achieve a small, incremental increase in production. The end result is a large step forward toward biofuel production, but the effort involved is intimidating.

Making fuel

Brewer's yeast, as the name implies, can already produce a biofuel: alcohol. But ethanol isn't a drop-in replacement for many current uses, which raises questions about its overall utility. If we have to re-engineer both our engines and our infrastructure in order to use it to replace fossil fuels, then there's not much space for a smooth transition away from gasoline and other liquid fuels.

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Radiohead.com unveils “The Radiohead Library,” an official band repository

Tons of great stuff, although there’s bad news if you rely on YouTube.

On Monday, British rock band Radiohead rolled out arguably the most comprehensive one-stop website for a single band we've ever seen—and for an Internet-savvy band like Radiohead, that's saying something.

The Radiohead Library, which can be found at the sensible URL of radiohead.com/library, includes nearly every official studio release since the band's debut album Pablo Honey launched in 1993, along with much, much more. Full concerts, TV appearances, CD booklet art, long-lost promotional videos: they're all here.

Whether you visit the site on a smartphone or desktop browser, it's formatted to present each Radiohead era as a series of squares and rectangles. The top of the site includes generic, single-colored squares, which each represent a major studio album. Click any of them to reveal the album, its associated EPs and singles, and a scattershot assortment of official music videos, full concert recordings, and other audio and video samples from that album's era. While you're picking through each era, you may notice squares with T-shirt logos. Turns out, these link to reprints of classic tour shirts and merchandise from almost every Radiohead album, back on sale for the first time in years.

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Boeing seeks $10 billion in loans as 737 Max crisis continues

Planes still grounded as another software problem was disclosed Friday.

Four Boeing 737 Max planes in the air.

Enlarge / Boeing 737 Max planes. (credit: Boeing)

Boeing is aiming to borrow $10 billion or more to help it get through the 737 Max crisis, CNBC reported today, citing people familiar with the matter.

"The company has secured at least $6 billion from banks so far, the people said, and is talking to other lenders for more contributions," CNBC wrote. Citigroup, Bank of America, Wells Fargo, and JPMorgan already agreed to loan Boeing money.

A Boeing 737 Max crash killed 189 people in October 2018 and another crash killed 159 people in March 2019. The US Federal Aviation Administration and governments from around the world ordered the grounding of 737 Max planes after the March crash.

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Wuhan outbreak triples as new coronavirus found to spread human-to-human

The WHO will hold an emergency meeting to assess the threat to public health.

A person in full, white protective suit, blue face mask, and goggles, helps wheel a patient on a gurney into a hospital. His hand is outstretched as if he is signaling someone not to come near.

Enlarge / Medical staff transfer patients to Jin Yintan hospital on January 17, 2020 in Wuhan, Hubei, China. (credit: Getty )

An outbreak of a never-before-seen coronavirus in the Chinese city of Wuhan dramatically worsened over the last few days with the case count more than tripling, cases appearing in new cities, and confirmation that the virus is spreading person-to-person.

The World Health Organization announced Monday that it will convene an emergency meeting on Wednesday, January 22, to assess the outbreak and how best to manage it

On Saturday, January 18, the Wuhan Municipal Health Commission reported 136 newly identified cases of the viral pneumonia and one additional death. On Tuesday, January 21 (local time 4:18am), the commission reported another death. That brings Wuhan’s totals to 198 cases and four deaths. Just one day earlier, on January 17, the health commission had reported just 62 cases and two deaths.

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Crytek, Cloud Imperium battle over how to end Star Citizen lawsuit

Both sides now want the case dismissed but for vastly different reasons.

Screenshot from the video game Star Citizen.

Enlarge / Ships full of lawyers descend on planet Cloud Imperium to deal with the fallout from this trial. (credit: Star Citizen)

Back in late 2017, we told you about Crytek's lawsuit against Star Citizen developer Cloud Imperium Games, over an "exclusive" license to use CryEngine in its titles. Now, over two years (and one failed settlement attempt) later, the two companies are fighting over how, exactly, that lawsuit should be dismissed.

The actual allegations and counter-allegations between Crytek and Cloud Imperium get pretty labyrinthine pretty quickly. But a core part of Crytek's argument is that its original agreement with Cloud Imperium only covered the use of CryEngine in Star Citizen and not the single-player Squadron 42 spin-off (Cloud Imperium disputes this characterization of the original license).

Technically, though, any supposed breach of Crytek's license won't actually take place until and unless Squadron 42 is actually released. And with that game's "staggered development" beta test recently pushed back to the third quarter of 2020, Crytek this month filed a motion to voluntarily dismiss its own lawsuit "without prejudice to re-filing those claims upon the actual release of Squadron 42." In essence, this "dismissal" would just delay the trial from its currently planned June start date to October 13 (if Squadron 42 has indeed come out by then).

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UFC 246 Twitch Piracy Fail Raises Questions For Amateur Pirates & UFC Alike

The much-heralded return of Conor McGregor this weekend ended in a stunning 40-second victory for the UFC’s biggest star. The event also resulted in one of the biggest piracy fails in recent memory when a Twitch user broadcasting the PPV event illegally managed to expose details of his personal life to more than 130,000 people. This incident and others like it raise questions not only for amateur pirates but also the UFC.

Source: TF, for the latest info on copyright, file-sharing, torrent sites and more. We also have VPN reviews, discounts, offers and coupons.

Conor McGregor is without doubt the biggest star the world of mixed martial arts has ever seen. Often controversial but always entertaining, the Irishman’s name on a pay-per-view event represents a financial windfall for everyone involved.

As a result, any card displaying McGregor’s name as one half of the main event attracts huge attention and last Saturday’s UFC 246 was no different. Taking place in a sold-out T-Mobile Arena in Las Vegas and broadcast live on PPV, millions of people parted with money to enjoy the extravaganza. Of course, countless thousands didn’t pay a penny to the UFC or its official broadcasting partners.

UFC 246 was widely available on ‘pirate’ IPTV services and unlicensed sports streaming sites over the weekend. However, it was also broadcast on platforms that have less of a bad reputation for piracy such as Twitch, for example, with one particular instance ending in disaster for the person behind the illicit stream.

On Saturday night and for reasons best known to him, Twitch user SkarrsWorld streamed the UFC 246 PPV on his channel to what appears to have been a fairly limited audience. However, during a promo section of the event featuring UFC light heavyweight champion Jon Jones, a personal message notification popped up on screen and was immediately broadcast along with the pirated PPV.

While the text in the message raises all sorts of questions, this disaster had the potential to go unnoticed to the wider public. However, an eagle-eyed viewer of the stream noticed the error and turned the section into a clip which was then shared around on social media.

Just a few hours ago it had already been seen at least 100,000 times and at the time of writing, more than 146,000 views are being reported. That’s a huge audience for what was originally a niche broadcast and while amusing for some, undoubtedly represents a serious breach for the streamer. Having private matters paraded in public is undesirable but in combination with intentional piracy of a PPV event, the gravity increases.

This rookie mistake raises questions of how easy it has become for Joe Public to get into live pirate streaming and the possible consequences for those who get into the game without considering their own security. This type of online infringement has traditionally been carried out by ‘professionals’ with experience of obtaining streams and broadcasting them securely but this Twitch debacle is miles apart. But the issues go deeper than that.

The clip featuring the private message is obviously terribly embarrassing but due to the manner in which the fight played out, the implications of streaming the Conor McGregor vs Donald Cerrone main event on a platform like Twitch are an even bigger cause for concern for the UFC.

From the moment the bell rang to the moment referee Herb Dean called off the fight following a McGregor onslaught, just 40 seconds had passed. To put that into perspective, a fight that had been hyped for weeks (and had dozens of hours of official broadcasting dedicated to it in the lead-up) was over in the space of a GIF. Or, more conveniently, in the Twitch clips that immediately spread like wildfire, even before McGregor could make his victory speech.

While those 40 seconds were just a small part of the pay-per-view, the rest of the card was relatively weak, especially for the casual fans the UFC hopes to scoop up every time McGregor fights. So, when viewed through the prism of considerable dollar costs to view, particularly in the United States, value for money probably wasn’t on the lips of many paying fans at the end of Saturday night.

A pirate Twitch stream or clip, on the other hand, is likely to have proven more than adequate for the passer-by looking for 40 seconds of pure mixed martial arts excitement. In a world where revenue is king, that’s not what the UFC ever wants to hear.

Source: TF, for the latest info on copyright, file-sharing, torrent sites and more. We also have VPN reviews, discounts, offers and coupons.

As attacks begin, Citrix ships patch for VPN vulnerability

Hundreds of US government agencies have vulnerable VPNs, data shows.

As attacks begin, Citrix ships patch for VPN vulnerability

Enlarge (credit: Igor Golovniov/SOPA Images/LightRocket via Getty Images)

On January 19, Citrix released some permanent fixes to a vulnerability on the company's Citrix Application Delivery Controller (ADC) and Citrix Gateway virtual private network servers that allowed an attacker to remotely execute code on the gateway without needing a login. The vulnerability affects tens of thousands of known VPN servers, including at least 260 VPN servers associated with US federal, state, and local government agencies—including at least one site operated by the US Army.

The patches are for versions 11.1 and 12.0 of the products, formerly marketed under the NetScaler name. Other patches will be available on January 24. These patches follow instructions for temporary fixes the company provided to deflect the crafted requests associated with the vulnerability, which could be used by an attacker to gain access to the networks protected by the VPNs.

Fermin J. Serna, chief information security officer at Citrix, announced the fixes in a blog post on Sunday. At the same time, Serna revealed that the vulnerability—and the patches being released—also applied to Citrix ADC and Citrix Gateway Virtual Appliances hosted on virtual machines on all commercially available virtualization platforms, as well as those hosted in Azure, Amazon Web Services, Google Compute Platform, and Citrix Service Delivery Appliances (SDXs).

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Astronomers find an oddball asteroid entirely inside the orbit of Venus

“Getting past the orbit of Venus must have been challenging.”

The Zwicky Transient Facility at Palomar Observatory in California.

Enlarge / The Zwicky Transient Facility at Palomar Observatory in California. (credit: Caltech Optical Observatories)

Astronomers have found nearly 1 million asteroids in our Solar System, with the vast majority located in the asteroid belt between Mars and Jupiter.

It is far rarer to find asteroids with orbits closer to the Sun, and especially inside the orbit of Earth, due to Jupiter's gravitational influence. There are only about 20 known asteroids with orbits entirely inside that of Earth's. They are called Atira asteroids.

Many of these Atira asteroids have orbits that are substantially tilted away from the plane of the Solar System, suggesting past encounters with Mercury or Venus.

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Frontier, an ISP in 29 states, plans to file for bankruptcy

Frontier subscribers suffer from poor customer service and failing networks.

A Frontier Communications service van parked in a snowy area.

Enlarge / A Frontier Communications service van. (credit: Mike Mozart)

Frontier Communications is planning to file for bankruptcy within two months, Bloomberg reported last week.

The telco "is asking creditors to help craft a turnaround deal that includes filing for bankruptcy by the middle of March, according to people with knowledge of the matter," Bloomberg wrote.

Frontier CEO Bernie Han and other company executives "met with creditors and advisers Thursday and told them the company wants to negotiate a pre-packaged agreement before $356 million of debt payments come due March 15," the report said. The move would likely involve Chapter 11 bankruptcy to let Frontier "keep operating without interruption of telephone and broadband service to its customers."

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Kickstarter: Gebundener Mars-Atlas zeigt Karten des Roten Planeten

The Mars-Atlas ist ein interessantes Buch: Es zeigt detaillierte Karten vom Mars statt der Erde. Mehr als 2.000 Standorte sind darauf zu sehen. Auch eine digitale Applikation wird angeboten, auf der Hobbyforscher ein 3D-Modell des Mars erkunden können …

The Mars-Atlas ist ein interessantes Buch: Es zeigt detaillierte Karten vom Mars statt der Erde. Mehr als 2.000 Standorte sind darauf zu sehen. Auch eine digitale Applikation wird angeboten, auf der Hobbyforscher ein 3D-Modell des Mars erkunden können - ähnlich wie bei Google Mars. (Mars, Google Earth)