Treating lymphoma with HIV-resistant stem cells “cures” another patient

This is the second time we’ve cleared HIV, and may help us learn what works.

A red blob with lots of smaller, red and green blobs attached to it.

Enlarge / Artist's conception of HIV attached to a cell. (credit: Ohio State)

The identification of the HIV virus ultimately led to the development of therapies that specifically target the virus' ability to make new copies of itself. These therapies have radically altered the lives of infected people, turning a often-lethal virus into something that can be managed for decades. But while the treatments control the virus, they don't eliminate it. Infected people still have reservoirs of virus in their bodies, raising the prospect that a drug-resistant strain could ultimately evolve.

There's only a single known case of the virus being eliminated entirely. That patient had a leukemia that could be treated with a blood stem-cell transplant, and his transplant team used cells that carried a mutation that eliminates one of the proteins that HIV uses to attach to cells. Today, researchers are reporting the second instance in which the transplantation of stem cells carrying this mutation has seemingly eliminated a viral infection. Two cases means the time has come to start looking for features in common between the two treatments.

HIV and stem cells

One of the reasons HIV is so difficult to eliminate is that the virus' normal lifecycle includes integrating a copy into the cell's DNA. Thus, even if all the circulating virus is eliminated, infected cells can just produce more. To eliminate the virus, you'd have to kill every single infected cell in a person's body. A variety of "reservoirs" of HIV-infected cells have been identified; all of the significant ones appear to be in immune cells of one type or another.

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Why is your wine crying? Scientists say shock waves likely play a role

Alcohol content, the pour, and shape of the glass are also factors in wine tears.

Wine tears are due to a difference in surface tension across the top of the wine, resulting from the alcohol evaporating faster than the water in the wine.

Enlarge / Wine tears are due to a difference in surface tension across the top of the wine, resulting from the alcohol evaporating faster than the water in the wine. (credit: YouTube/Applied Science)

Perhaps you've noticed a ring of clear liquid near the top of your glass of wine, with droplets forming and dropping back into the wine. These are "tears of wine," also known as wine legs or "fingers." Physicists have been intrigued by them for over 150 years, and while the basic mechanism is understood, new research indicates that shock-wave dynamics may also play a role in their formation.

UCLA engineer Andrea Bertozzi described her recent work on the subject today in Boston at the 2019 March meeting of the American Physical Society, the largest annual physics conference in the country. "There's been a flurry of activity over the last 30 years trying to understand more about this phenomenon, but nothing that really addressed the dynamics of the actual tear formation," she said. Adding shock waves into the explanatory mix "would explain why sometimes one sees tears of wine and sometimes one does not."

British physicist James Thomson (elder brother to Lord Kelvin) first noticed wine tears in 1855, although they're technically known as the Marangoni effect after Italian physicist Carlo Marangoni. The phenomenon is also responsible for the infamous "coffee ring effect," which has also generated much interest among physicists. It's most notable in wines (or other spirits like rum) with alcohol content at least as high as 13.5 percent. (That's because alcohol has a lower surface tension than water.) If you spread a thin film of water on your kitchen counter and place a single drop of alcohol in the center, you'll see the water flow outward, away from the alcohol. The difference in their alcohol concentrations creates a surface tension gradient, driving the flow.

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Weirdly interconnected qubits give D-Wave a big jump in performance

D-Wave’s architecture becomes more complex while machine gets faster, more capable.

"The Great Wave off Kanagawa," a 19th-century woodcut print by Japanese artist Katsushika Hokusai.

Enlarge / "The Great Wave off Kanagawa," a 19th-century woodcut print by Japanese artist Katsushika Hokusai. (credit: Public domain)

Last week, D-Wave announced a new version of its quantum annealing computer. The new machine includes a number of technical improvements, as well as a significant change to the physical arrangement of the board. What does all this mean? Combined with D-Wave's online resources, a tool that verges on useful is starting to take form.

Making a smooth computer

Before we reach the gooey chocolate center, we have to deal with the crusty outer coating: what is a quantum annealer? Most computers work in a straightforward manner: to add two numbers together, you construct a set of logical gates that will perform addition. Each of these gates performs a set of specific and clearly defined operations on its input.

But that is not the only way to perform computation. Most problems can be rewritten so that they represent an energy minimization problem. In this picture, the problem is an energy landscape, and the solution is the lowest-possible energy of that landscape. The trick is finding the combination of bit values that represents that energy.

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Dealmaster: A whole bunch of Anker charging gear is on sale today

Plus the PS4 Pro for $360, a 128GB microSD card for $21, iPad deals, and more.

Dealmaster: A whole bunch of Anker charging gear is on sale today

Enlarge (credit: TechBargains)

Greetings, Arsians! Courtesy of our friends at TechBargains, we have another round of deals to share. Today's list is headlined by a one-day sale on Anker charging accessories at Amazon, covering a number of portable batteries, wall chargers, and charging cables.

The sale does not include a ton of USB-C gear, unfortunately, but most of what's available is at or near all-time lows and can still be useful for newer gadgets if you own a USB-A to USB-C cable. Some highlights include a 60W six-port desktop charger for $21, a 30W USB-C PD wall charger—which is fast enough to charge newer smartphones at max speeds—for $18, a 20,100mAh power bank for $40, and a three-pack of Lightning cables for $17. Everything here is a commodity, but Anker has carved out a reputation for making these things reliable over the years, and most of the items on sale come with an 18-month warranty on the off-chance that they go bad.

If you don't need to stock up on charging gear, we also have another one-day sale on HyperX gaming tech, plus discounts on the 9.7-inch iPad, the PlayStation 4 Pro, Samsung microSD cards, and much more. Have a look for yourself below.

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Dealmaster: A whole bunch of Anker charging gear is on sale today

Plus the PS4 Pro for $360, a 128GB microSD card for $21, iPad deals, and more.

Dealmaster: A whole bunch of Anker charging gear is on sale today

Enlarge (credit: TechBargains)

Greetings, Arsians! Courtesy of our friends at TechBargains, we have another round of deals to share. Today's list is headlined by a one-day sale on Anker charging accessories at Amazon, covering a number of portable batteries, wall chargers, and charging cables.

The sale does not include a ton of USB-C gear, unfortunately, but most of what's available is at or near all-time lows and can still be useful for newer gadgets if you own a USB-A to USB-C cable. Some highlights include a 60W six-port desktop charger for $21, a 30W USB-C PD wall charger—which is fast enough to charge newer smartphones at max speeds—for $18, a 20,100mAh power bank for $40, and a three-pack of Lightning cables for $17. Everything here is a commodity, but Anker has carved out a reputation for making these things reliable over the years, and most of the items on sale come with an 18-month warranty on the off-chance that they go bad.

If you don't need to stock up on charging gear, we also have another one-day sale on HyperX gaming tech, plus discounts on the 9.7-inch iPad, the PlayStation 4 Pro, Samsung microSD cards, and much more. Have a look for yourself below.

Read 6 remaining paragraphs | Comments

China’s “democracy” includes mandatory apps, mass chat surveillance

Researcher discovers servers in China collecting data on 364 million social media profiles daily.

Deputies of the 13th National People's Congress listen to Chinese Premier Li Keqiang's speech during the opening of the Two Sessions at The Great Hall of People on March 5, 2019 in Beijing, China.

Enlarge / Deputies of the 13th National People's Congress listen to Chinese Premier Li Keqiang's speech during the opening of the Two Sessions at The Great Hall of People on March 5, 2019 in Beijing, China. (credit: y Andrea Verdelli/Getty Images)

As the National People's Congress gathers in Beijing for the beginning of China's "Two Sessions" political season, state media is making an international propaganda push on social media—including on platforms blocked by China's "Great Firewall"—to promote China's "system of democracy."

That system of democracy apparently involves mass surveillance to tap into the will of the people. While China's growth as a surveillance state has been well-documented, the degree to which the Chinese leadership uses digital tools to shape the national political landscape and to control Chinese citizens has grown even further recently. That's because authorities have been tapping directly into Chinese Communist Party (CCP) members' and other Chinese citizens' online activities and social media profiles.

The little red app

The China Media Project reports that the CPP has mandated party members download a new smartphone application called "Xi Study (Xue Xi) Strong Nation" (学习强国)—an application that provides a library of articles and videos carrying the teachings of Chinese President Xi Jinping. Party and government groups were to institute mandatory group training periods using Xi Study—similar to the periods of study of Mao's "Little Red Book" once required by the party.

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“Legal Product Everywhere” is Best Defense Against Football Piracy

The executive vice president of strategy for Germany’s powerful Bundesliga football league says that competing with piracy begins with having “legal product everywhere.” It’s a common sense approach but the lack of options in many countries continually drives huge numbers of fans to piracy every week.

Source: TF, for the latest info on copyright, file-sharing, torrent sites and more. We also have VPN reviews, discounts, offers and coupons.

Dedicated fans of top-tier soccer (or football, as it’s more widely known in Europe) who don’t attend matches generally have to pay for the privilege to watch on TV.

In many countries, the only options are expensive ones, which can be reason enough for some to bypass the system altogether and turn to piracy. But even those who can pay the prices aren’t always offered what they need.

In the UK, for example, the 3pm Saturday ‘blackout’ means that some of the most important Premier League games ever played simply aren’t available to the public on TV as they happen. As a result, Saturday afternoons now feature a secondary game of finding a pirate stream online in order to watch something that isn’t legally available on home turf, at any price.

The Premier League tries to combat this activity in collaboration with local ISPs via ‘dynamic blocking‘ but while this has had some effect in the past, anecdotal evidence on dedicated piracy forums suggests that pirates have begun to adapt, so this is having only a limited effect.

While several big leagues in Europe would also like to have these kinds of blocking tools at their disposal, it’s blatantly obvious that they can’t compete with piracy if they aren’t offering customers what they want legally. It’s a sentiment shared by Arne Rees, executive vice president of strategy for Germany’s powerful Bundesliga.

“One of the best defenses against [piracy] is certainly having legal product everywhere,” Rees said, as cited by SportsVideo.org.

“If a fan simply can’t get you, their mind-set is, I want to watch it, and, if only a pirated stream is available, they will justify that.

“At the very least. we have to create an environment where legal product competes with the illegal product. The legal product will always be the better product,” Rees added.

This isn’t to say that legal football content isn’t available to fans already.

Bundesliga matches are broadcast to more than 200 countries around the world, as are matches from the Premier League. However, licensing deals mean that fans are almost always restricted in some way, either through prevention of watching key matches live, or even having access to them at all.

For example, TV 2 – Norway’s largest commercial television broadcaster – has had the rights to show Premier League matches since 2010 and last year struck a new deal which extends to 2022.

The company doesn’t want to reveal how much it paid this time around but for the preceding three years paid around NOK 1.9 billion (around $220m). Nevertheless, it still has a piracy problem and it’s mostly about availability.

In 2019, TV 2 has the rights to show 205 matches, which is around half of those actually played. This means that when crunch matches appear in the other half, hooked fans must either miss out on the action, or turn to piracy.

A report by Aftenposten last month detailed how fans were shut out of the key match between Everton and Manchester City so turned to pirate streams instead. Sarah Willand, Communications Director at TV 2, said the company understands the dilemma faced by fans.

“We would be happy to broadcast all the matches so that people see everything from the Premier League,” Willand said.

“I therefore understand people’s frustration, it’s annoying not to be able to watch their favorite team on TV when you have a subscription.”

Of course, companies like TV 2 are countering by warning consumers that unlicensed services offering matches are illegal, which is correct. However, claims that subscription IPTV services – the main competitor to legal offerings – are dangerous (viruses etc), are at best speculative and at worst, completely untrue.

Apart from being available at a very cheap price (easy when you don’t have to pay for content, of course), what these subscription services do (very effectively) is cut through all the red tape. Prohibitive licensing deals are completely ignored, so fans in Norway get all the matches. Fans in the UK get ‘banned’ Premier League matches on Saturday afternoons.

This is achieved by cherry-picking football content from all over the world. Premier League content that isn’t shown on a Saturday afternoon can be available in Canada, for example. Matches that aren’t available in Norway might be available in several other regions, on several different channels. So, the IPTV providers scoop them all up, to ensure that fans can watch all the matches, wherever they are.

This, of course, is completely illegal and to some extent probably hurts the earning potential of the various leagues around Europe and their broadcasting partners. However, it’s clear that the companies involved have the power – if they so choose – to solve this problem by offering all content, to all people, wherever they are, at a fair price.

Given the tangle of licensing agreements across dozens of regions, this is much – much – more easily said than done, few people will argue with that. But the cold, hard truth is that most fans don’t care. If they can’t get matches legally (and particularly if they already have an underperforming subscription service), many will feel justified turning to the high seas.

And it doesn’t matter how ‘clever’ blocking gets either.

A little over a month ago, a person in charge of a licensed premises quickly showed TF an IPTV service offering HD streams of Premier League matches (on a Saturday and all week, for that matter) for £2 per month – along with more than 6,000 other channels too.

The only motivation for this person to buy this package was access to 3pm Saturday football, on top of an already expensive Sky subscription that only offers just over 120 matches per season, which is 85 matches less than Norwegian viewers get on TV 2. Why should that draw any understanding from UK subscribers?

Now, via this cheap IPTV service, the person we spoke with finds he can watch all matches and has no need for the Sky package either – talk about counter-productive. Something really needs to be done because blocking is not going to solve this problem.

Make it available legally, at a fair price, everywhere. Or get eaten by pirates.

Source: TF, for the latest info on copyright, file-sharing, torrent sites and more. We also have VPN reviews, discounts, offers and coupons.

New Fire HD 8 bootloader unlock method doesn’t require opening the case

It’s been possible to unlock the bootloader and root the latest Amazon Fire HD 8 tablet since January. But up until recently the only known method for doing that involved prying open the tablet’s case, identifying points on the motherboard,…

It’s been possible to unlock the bootloader and root the latest Amazon Fire HD 8 tablet since January. But up until recently the only known method for doing that involved prying open the tablet’s case, identifying points on the motherboard, and shorting them to enter bootrom mode. But now there’s an easier way. Xda-developers forum […]

The post New Fire HD 8 bootloader unlock method doesn’t require opening the case appeared first on Liliputing.

Netcologne: Lokaler Netzbetreiber will eigenes 5G-Netz aufbauen

Interessenten für lokale 5G-Netze gibt es einige. Im Raum Köln-Bonn will Netcologne gerne etwas Eigenes anbieten, doch seitens der Bundesnetzagentur sind die Rahmenbedingungen noch nicht geklärt. (Telefónica, Telekom)

Interessenten für lokale 5G-Netze gibt es einige. Im Raum Köln-Bonn will Netcologne gerne etwas Eigenes anbieten, doch seitens der Bundesnetzagentur sind die Rahmenbedingungen noch nicht geklärt. (Telefónica, Telekom)

Daily Deals (3-05-2019)

Amazon is running a 1-day sale on Anker charging accessories, which means you can pick up a 10,000 mAh battery pack for $20, a pretty decent 30W travel charger for $17, or a car charger that’s also an FM transmitter and Bluetooth receiver for $19…

Amazon is running a 1-day sale on Anker charging accessories, which means you can pick up a 10,000 mAh battery pack for $20, a pretty decent 30W travel charger for $17, or a car charger that’s also an FM transmitter and Bluetooth receiver for $19. Here are some of the day’s best deals. Batteries & […]

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