Doctors tried to lower $148K cancer drug cost; makers triple price of pill

“That got us kind of p—ed off,” doctor said after learning of price jump.

(credit: Wellness GM)

A drug that treats a variety of white blood cell cancers typically costs about $148,000 a year, and doctors can customize and quickly adjust doses by adjusting how many small-dose pills of it patients should take each day—generally up to four pills. At least, that was the case until now.

Last year, doctors presented results from a small pilot trial hinting that smaller doses could work just as well as the larger dose—dropping patients down from three pills a day to just one. Taking just one pill a day could dramatically reduce costs to around $50,000 a year. And it could lessen unpleasant side-effects, such as diarrhea, muscle and bone pain, and tiredness. But just as doctors were gearing up for more trials on the lower dosages, the makers of the drug revealed plans that torpedoed the doctors’ efforts: they were tripling the price of the drug and changing pill dosages.

The drug, ibrutinib (brand name Imbruvica), typically came in 140mg capsules, of which patients took doses from 140mg per day to 560mg per day depending on their cancer and individual medical situation. (There were also 70mg capsules for patients taking certain treatment combinations or having liver complications.) The pills treat a variety of cancers involving a type of white blood cell called B cells. The cancers include mantle cell lymphoma, which was approved for treatment with four 140mg pills per day, and chronic lymphocytic leukemia, approved to be treated with three 140mg pills per day. Each 140mg pill costs somewhere around $133—for now.

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Deals of the Day (4-19-2018)

It’s not unusual to find a set of Bluetooth earbuds selling for $20 or less. What is a little unusual is to find a set of Bluetooth on-ear headphones in that price range. But right now TaoTronics is selling a set for just $20 at Amazon when you use the…

It’s not unusual to find a set of Bluetooth earbuds selling for $20 or less. What is a little unusual is to find a set of Bluetooth on-ear headphones in that price range. But right now TaoTronics is selling a set for just $20 at Amazon when you use the coupon code MG4RTLKL. That’s about $16 off the normal […]

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Better than reality: New emulation tech lags less than original consoles

“LAGFIX” fast-forwards through “hidden” frames for near-instant response times.

This video comparison shows how RetroArch emulation can actually react to button inputs more quickly than original NES hardware.

Here at Ars, we've previously written about how difficult it is to perfectly emulate classic video game consoles even with powerful modern computer hardware. Now, the coders behind the popular RetroArch multi-emulator frontend are working to make their emulation better than perfect, in a way, by removing some of the input latency that was inherent in original retro gaming hardware.

While early game consoles like the Atari 2600 sample and process user inputs between frames, consoles since the NES usually run that game logic while a frame is rendering. That means the game doesn't output its reaction to a new input until the next frame after the button is pressed at earliest. In some games, the actual delay can be two to four frames (or more), which can start to be a noticeable lag at the usual 60 frames per second (or about 17 ms per frame).

An experimental Input Lag Compensation mode being rolled out in new versions of RetroArch fixes this issue by basically fast-forwarding a few hidden frames behind the scenes before displaying that first "reaction" frame in the expected spot. So in a game like Sonic the Hedgehog, which has two frames of input lag, the game will quickly emulate two additional, hidden frames after every new input. Then, the emulator actually shows the third post-input frame (where Sonic first shows a visible reaction) timed for when the first post-input frame would naturally appear, cutting out the delay a player would usually see.

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Amazon’s Alexa Skill Blueprints lets you teach Alexa new tricks without learning to code

Amazon’s Alexa voice service can do a lot of things. You can ask an Alexa-enabled device like an Echo speaker or a Fire tablet for traffic, news, or weather updates. You can add things to your grocery list. And, of course, you can use it to order items…

Amazon’s Alexa voice service can do a lot of things. You can ask an Alexa-enabled device like an Echo speaker or a Fire tablet for traffic, news, or weather updates. You can add things to your grocery list. And, of course, you can use it to order items from Amazon just by talking to Alexa. […]

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Notebooks: Lenovos Business-Thinkpads mit Ryzen Mobile zeigen sich

In den kommenden Wochen dürften die ersten Thinkpads für den professionellen Einsatz mit mobilen AMD-Prozessoren auf den Markt kommen. Zusätzlich zu zwei Displaygrößen gibt es zahlreiche Konfigurationen und Robustheit. (Business-Notebooks, AMD)

In den kommenden Wochen dürften die ersten Thinkpads für den professionellen Einsatz mit mobilen AMD-Prozessoren auf den Markt kommen. Zusätzlich zu zwei Displaygrößen gibt es zahlreiche Konfigurationen und Robustheit. (Business-Notebooks, AMD)

Pirates Taunt Amazon Over New “Turd Sandwich” Prime Video Quality

Discerning distributors and consumers of pirated content are lambasting Amazon for an unannounced drop in video quality from its Prime service this week. In a move that affects paying customers as well as those on the high seas, one release group has colorfully described Amazon’s efforts as a choice between a “turd sandwich” and a “giant douche”.

Source: TF, for the latest info on copyright, file-sharing, torrent sites and more. We also have VPN reviews, discounts, offers and coupons.

Even though they generally aren’t paying for the content they consume, don’t fall into the trap of believing that all pirates are eternally grateful for even poor quality media.

Without a doubt, some of the most quality-sensitive individuals are to be found in pirate communities and they aren’t scared to make their voices known when release groups fail to come up with the best possible goods.

This week there’s been a sustained chorus of disapproval over the quality of pirate video releases sourced from Amazon Prime. The anger is usually directed at piracy groups who fail to capture content in the correct manner but according to a number of observers, the problem is actually at Amazon’s end.

Discussions on Reddit, for example, report that episodes in a single TV series have been declining in filesize and bitrate, from 1.56 GB in 720p at a 3073 kb/s video bitrate for episode 1, down to 907 MB in 720p at just 1514 kb/s video bitrate for episode 10.

Numerous theories as to why this may be the case are being floated around, including that Amazon is trying to save on bandwidth expenses. While this is a possibility, the company hasn’t made any announcements to that end.

Indeed, one legitimate customer reported that he’d raised the quality issue with Amazon and they’d said that the problem was “probably on his end”.

“I have Amazon Prime Video and I noticed the quality was always great for their exclusive shows, so I decided to try buying the shows on Amazon instead of iTunes this year. I paid for season pass subscriptions for Legion, Billions and Homeland this year,” he wrote.

“Just this past weekend, I have noticed a significant drop in details compared to weeks before! So naturally I assumed it was an issue on my end. I started trying different devices, calling support, etc, but nothing really helped.

“Billions continued to look like a blurry mess, almost like I was watching a standard definition DVD instead of the crystal clear HD I paid for and have experienced in the past! And when I check the previous episodes, sure enough, they look fantastic again. What the heck??”

With Amazon distancing itself from the issues, piracy groups have already begun to dig in the knife. Release group DEFLATE has been particularly critical.

“Amazon, in their infinite wisdom, have decided to start fucking with the quality of their encodes. They’re now reaching Netflix’s subpar 1080p.H264 levels, and their H265 encodes aren’t even close to what Netflix produces,” the group said in a file attached to S02E07 of The Good Fight released on Sunday.

“Netflix is able to produce drastic visual improvements with their H265 encodes compared to H264 across every original. In comparison, Amazon can’t decide whether H265 or H264 is going to produce better results, and as a result we suffer for it.”

Arrr! The quality be fallin’

So what’s happening exactly?

A TorrentFreak source (who tells us he’s been working in the BluRay/DCP authoring business for the last 10 years) was kind enough to give us two opinions, one aimed at the techies and another at us mere mortals.

“In technical terms, it appears [Amazon has] increased the CRF [Constant Rate Factor] value they use when encoding for both the HEVC [H265] and H264 streams. Previously, their H264 streams were using CRF 18 and a max bitrate of 15Mbit/s, which usually resulted in file sizes of roughly 3GB, or around 10Mbit/s. Similarly with their HEVC streams, they were using CRF 20 and resulting in streams which were around the same size,” he explained.

“In the past week, the H264 streams have decreased by up to 50% for some streams. While there are no longer any x264 headers embedded in the H264 streams, the HEVC streams still retain those headers and the CRF value used has been increased, so it does appear this change has been done on purpose.”

In layman’s terms, our source believes that Amazon had previously been using an encoding profile that was “right on the edge of relatively good quality” which kept bitrates relatively low but high enough to ensure no perceivable loss of quality.

“H264 streams encoded with CRF 18 could provide an acceptable compromise between quality and file size, where the loss of detail is often negligible when watched at regular viewing distances, at a desk, or in a lounge room on a larger TV,” he explained.

“Recently, it appears these values have been intentionally changed in order to lower the bitrate and file sizes for reasons unknown. As a result, the quality of some streams has been reduced by up to 50% of their previous values. This has introduced a visual loss of quality, comparable to that of viewing something in standard definition versus high definition.”

With the situation failing to improve during the week, by the time piracy group DEFLATE released S03E14 of Supergirl on Tuesday their original criticism had transformed into flat-out insults.

“These are only being done in H265 because Amazon have shit the bed, and it’s a choice between a turd sandwich and a giant douche,” they wrote, offering these images as illustrative of the problem and these indicating what should be achievable.

With DEFLATE advising customers to start complaining to Amazon, the memes have already begun, with unfavorable references to now-defunct group YIFY (which was often chastized for its low quality rips) and even a spin on one of the most well known anti-piracy campaigns.

You wouldn’t download stream….

TorrentFreak contacted Amazon Prime for comment on both the recent changes and growing customer complaints but at the time of publication we were yet to receive a response.

Source: TF, for the latest info on copyright, file-sharing, torrent sites and more. We also have VPN reviews, discounts, offers and coupons.

AMD’s 2nd-gen Ryzen desktop chips released, bringing better performance for the same price (or less)

AMD’s Ryzen 2000 series desktop chips went up for pre-order last week, and now they’re available for purchase for $199 and up. The 2nd-gen Ryzen chips are based on a new Zen+ architecture and manufactured using a 12nm process, all of which brings a mod…

AMD’s Ryzen 2000 series desktop chips went up for pre-order last week, and now they’re available for purchase for $199 and up. The 2nd-gen Ryzen chips are based on a new Zen+ architecture and manufactured using a 12nm process, all of which brings a modest boost in performance and efficiency over last year’s chips. We’ll […]

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Adblock Plus: Bundesgerichtshof erlaubt Einsatz von Werbeblockern

Der Bundesgerichtshof hat im Streit um die Nutzung von Werbeblockern entschieden: Eyeo verstößt mit Adblock Plus gegen keine Gesetze. Axel Springer hat nach dem Urteil angekündigt, Verfassungsbeschwerde einreichen zu wollen. (AdBlocker, Internet)

Der Bundesgerichtshof hat im Streit um die Nutzung von Werbeblockern entschieden: Eyeo verstößt mit Adblock Plus gegen keine Gesetze. Axel Springer hat nach dem Urteil angekündigt, Verfassungsbeschwerde einreichen zu wollen. (AdBlocker, Internet)

New Alexa Blueprints let users make custom skills without knowing any code

Like Mad Libs for Alexa, “blueprints” take a fill-in-the-blank approach to skills.

Enlarge (credit: Amazon)

Amazon just released a new way for Alexa users to customize their experience with the virtual assistant. New Alexa Skill Blueprints allow users to create their own personalized Alexa skills, even if they don't know how to code. These "blueprints" act as templates for making questions, responses, trivia games, narrative stories, and other skills with customizable answers unique to each user. Amazon already has a number of resources for developers to make the new skills they want, but until now, users have had to work within the confines of pre-made Alexa skills.

Currently, more than 20 templates are available on the new Alexa Skill Blueprints website, all ready for Alexa users to personalize with their own content. Let's say you want to make a personalized trivia game for your family and friends: choosing the Trivia blueprint brings up more information about how this particular blueprint works, including audio examples and instructions on how to fill out the template. Click "Make Your Own" to then write your own trivia questions, possible answers, and choose which answer is correct for each question. You can even add sound effects like applause to make the game feel more real. After naming your trivia game, it will be accessible within minutes on all of the Alexa devices associated with your Amazon account.

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Velodyne invented modern lidar—it’s about to face real competition

We talked to Austin Russell, CEO of lidar startup Luminar.

Enlarge / Velodyne's lidars aren't the only game in town any more. (credit: Velodyne)

David Hall invented modern three-dimensional lidar more than a decade ago for use in the DARPA Grand Challenge competitions. His company, Velodyne, has dominated the market for self-driving car lidar ever since. Last year, Velodyne opened a factory that it said had the capacity to produce a million lidar units in 2018—far more than any other maker of high-end lidars.

Now Velodyne is starting to see some serious competition. Last week, lidar startup Luminar announced that it was beginning volume production of its own lidar units. The company expects to produce 5,000 units per quarter by the end of 2018.

Meanwhile, Israeli startup Innoviz is also getting ready to manufacture its InnovizPro lidar in significant volume. The company declined to give Ars exact production numbers, only telling us it has orders for thousands of units. Innoviz believes it can scale up manufacturing quickly to satisfy that demand.

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