Blind cavefish have fishy diabetes precursor and still seem healthy

Their genes show how complicated insulin really is.

Enlarge (credit: Zachary Zakibe)

The Mexican tetra comes in different flavors. In normal river habitats, it’s a small, standard-looking, silvery fish. But some groups within the species have made their home in dark, food-scarce caves. Evolution has quickly rid these groups of their resource-hungry eyes and turned them into pinkish, chubby, blind cavefish—with a bunch of metabolic changes that help them survive in the extreme environment.

A paper in Nature this week reports that the cavefish are resistant to insulin, a condition that can cause damage on its own and is often a precursor to diabetes. But the fish somehow don’t suffer the same kinds of tissue damage that humans do we when have insulin resistance. The authors of the paper, led by Harvard geneticist Misty Riddle, report on how they tried to get to the bottom of the genetic mutations that contribute to this metabolic mystery. Their results show just how much variety exists in how different species respond to insulin—and that studying these fish more could help our understanding of diabetes.

High blood sugar

After you eat something, your blood sugar rises, and your pancreas releases insulin to deal with the increase. The insulin binds to specialized receptors, found on the surfaces of muscle, fat, and liver cells, telling them to absorb glucose from the blood. In between meals when blood glucose levels drop, a different hormone (glucagon) prompts the liver to release its stored glucose back into the blood.

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Mintbox Mini 2: Compact Linux desktop with Apollo Lake quad-core CPU

The Linux Mint team have announced that their next Mintbox mini PC is coming this summer. The Mintbox Mini 2 is a fanless computer that measures 4.4″ x 3.3″ x 1.3″ and weighs about 12 ounces. It’s powered by a 10W Intel Celeron J3455 quad-core processo…

The Linux Mint team have announced that their next Mintbox mini PC is coming this summer. The Mintbox Mini 2 is a fanless computer that measures 4.4″ x 3.3″ x 1.3″ and weighs about 12 ounces. It’s powered by a 10W Intel Celeron J3455 quad-core processor.   Prices are expected to start at $299 when […]

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Chinese space station will fall to Earth within two weeks

No nation likes to lose a piece of space hardware like this.

Enlarge / Tiangong-1 altitude decay forecast as of March 22, 2018. (credit: ESA)

China's first space station may fall to the ground as soon as one week from now, and certainly within two, orbital debris experts with the European Space Agency (ESA) say. Scientists, however, still cannot predict with any confidence where pieces of the 10.4-meter long Tiangong-1 station, which is traveling at 17,000 km/h, will land.

The latest estimate from the ESA indicates the station will enter Earth's atmosphere between March 30 and April 3, at which time most of the station will burn up. However, the station is large enough—it weighed 8.5 tons when fully fueled but has since used much of that propellant—that some pieces will very likely reach the planet's surface.

Beyond the fact that the station will reach a final impact point somewhere between 42.8 degrees north and 42.8 degrees south in latitude and probably near the northern or southern extremity of those boundaries due to Tiangong-1's orbital inclination, it is not possible to say where on Earth the debris will land. However, the likelihood of it affecting humans is quite low. Scientists estimate the "personal probability of being hit by a piece of debris from the Tiangong-1" is about 10 million times smaller than the annual chance of being hit by lightning.

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Congress votes for spending bill without Trump energy cuts; Trump may veto it

Office of Energy Efficiency and Renewable Energy would see a 14-percent funding increase.

Enlarge (credit: CatLane / Getty Images)

On Friday morning, the US Senate passed a $1.3 trillion spending bill which could avert yet another government shutdown. Although the bill covers the breadth of US government activities, one interesting outcome of budget negotiations is that the spending bill reflects none of President Trump's most drastic proposed cuts to Department of Energy (DOE) and Environmental Protection Agency (EPA) renewable energy and early-stage energy programs.

In fact, the omnibus spending bill, which would secure funding out to September 2018, even increased the budgets of some renewable energy programs.

Still, it's unclear if the bill will escape a veto from Trump. Politico reported on Thursday that the president was in favor of the bill, but on Friday he tweeted that he might veto it due to the fact that the bill did not include funding for a border wall.

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Deals of the Day (3-23-2018)

Samsung’s Level On wireless noise canceling headphones may not be in the same class as the latest high-end Bose or Sony models. But they’re also a lot more affordable: I picked up a pair when they were on sale for $70 last year, and I’ve been very impr…

Samsung’s Level On wireless noise canceling headphones may not be in the same class as the latest high-end Bose or Sony models. But they’re also a lot more affordable: I picked up a pair when they were on sale for $70 last year, and I’ve been very impressed with the noise cancellation, sound quality, and […]

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DNC “lone hacker” Guccifer 2.0 pegged as Russian spy after opsec fail

“Hacktivist” logged into a social media account from an IP address at GRU HQ in Moscow.

Vladimir Putin at an award ceremony at the Museum of the GRU, Russia's military intelligence agency. A GRU officer was reportedly behind the creation of the Guccifer 2.0 persona. (credit: Office of the President of Russia)

Soon after the June 2016 announcement by CrowdStrike that the Democratic National Committee's network had been the victim of a long-running breach perpetrated by Russian intelligence agencies, someone going by the name "Guccifer 2.0" suddenly materialized to take credit for the breach. Guccifer 2.0 started leaking internal DNC documents soon after. Intelligence officials and security experts have previously insisted that Guccifer 2.0 was in fact part of a Russian intelligence information operations campaign and not, as the person or persons behind the blog and social media accounts associated with the Guccifer 2.0 identity insisted, a Romanian hacker inspired by the original Guccifer.

Now, the Daily Beast reports that intelligence officials had direct evidence of Guccifer's true identity. One of the individuals maintaining Guccifer 2.0's social media presence forgot to use a virtual private network to access a US-based social media platform, thus leaving an Internet Protocol address located in Moscow in the service's logs. Working from that address, a source told the Daily Beast's Spencer Ackerman and Kevin Poulsen that analysts were able to dig deeper and associate Guccifer 2.0 with a single individual: "a GRU officer working out of the agency’s headquarters on Grizodubovoy Street in Moscow," Paulson and Ackerman reported. (The GRU, or Russian General Main Staff Intelligence Directorate, is Russia's largest foreign intelligence agency.)

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FTTH: Deutsche Glasfaser erreicht fast immer die Ausbauquote

Laut Firmenchef Uwe Nickl wird die Quote von 40 Prozent Kundennachfrage, die die Deutsche Glasfaser zur Voraussetzung für den Ausbau macht, meist schnell erreicht. Im weiteren Verlauf steige die Kundenzahl von Deutsche Glasfaser dann verlässlich. (Voda…

Laut Firmenchef Uwe Nickl wird die Quote von 40 Prozent Kundennachfrage, die die Deutsche Glasfaser zur Voraussetzung für den Ausbau macht, meist schnell erreicht. Im weiteren Verlauf steige die Kundenzahl von Deutsche Glasfaser dann verlässlich. (Vodafone, Glasfaser)

Controversial Roku ‘Piracy’ Ban Stays in Place in Mexico

Last year the Superior Court of Justice of the City of Mexico responded to a copyright complaint filed by a TV company by banning all imports and sales of Roku devices. After a temporary suspension of the decision, the ban soon returned and the company and various sales outlets have been fighting ever since. New rulings mean that the controversial restrictions will continue, at least for now.

Source: TF, for the latest info on copyright, file-sharing, torrent sites and more. We also have VPN reviews, discounts, offers and coupons.

‘Set-top’ devices such as Amazon’s Fire TV have sold in their millions in recent years as the stream-to-your-living room craze continues.

Many commercial devices are intended to receive official programming in a legal manner but most can be reprogrammed to do illegal things.

Of course, this behavior has nothing to do with the manufacturers of such devices but a case launched in Mexico last year really took things to the next level.

Following a complaint filed by cable TV provider Cablevision, the Superior Court of Justice of the City of Mexico handed down an order in June preventing the importation of Roku devices and prohibiting stores such as Amazon, Liverpool, El Palacio de Hierro, and Sears from putting them on sale.

The ban was handed down in an effort to tackle the amount of pirated content being viewed through the devices. News circulating at the time suggested that sellers on social media were providing more than 300 channels of unauthorized content for around US$8 per month.

Of course, the same illegal content consumption also takes place via regular PCs, tablet computers, and even mobile phones. No one would consider banning them but the court in Mexico clearly didn’t see the parallels when it dropped the hammer on Roku.

Later that month, however, a light appeared at the end of the tunnel. A federal judge decided to temporarily suspend the import and sales ban, which also instructed banks to stop processing payments from accounts linked to third-party pirate services.

“Roku is pleased with today’s court decision, which paves the way for sales of Roku devices to resume in Mexico,” Roku’s General Counsel Steve Kay informed TorrentFreak at the time.

“Piracy is a problem the industry at large is facing. We prohibit copyright infringement of any kind on the Roku platform. We actively work to prevent third-parties from using our platform to distribute copyright infringing content. Moreover, we have been actively working with other industry stakeholders on a wide range of anti-piracy initiatives.”

But just as the sales began to flow once more, the celebrations were almost immediately cut short.

On June 28, 2017, a Mexico City tribunal upheld the previous decision which banned importation and distribution of Roku devices, much to the disappointment of Roku’s General Counsel.

“Today’s decision is not the final word in this complex legal matter,” Steve Kay said.

Indeed, since that date, Roku and retailers including Amazon, Walmart, Best Buy, Office Depot, Radio Shack and Sears have been fighting to have Roku devices put back on sale again, with several courts ruling against the appeals. Then last week there was another blow when federal judges in Mexico City and Torreón decided to keep the original suspension in place.

Forbidding the “importation, commercialization and distribution” of Roku devices, the judges maintained that Roku devices could be used as an instrument for “dishonest commerce” in violation of Mexico’s copyright law.

The main argument in support of the ban is that Roku devices can still be used by people to gain access to infringing content. As a result, Cablevision believes that Roku should modify its devices to ensure that piracy isn’t possible in the future.

“It is necessary for Roku to make adjustments to its software, as other online content distribution platforms do, so that violations of copyrighted content do not take place,” a Cablevision spokesperson said.

The decision to ban Roku devices can still be appealed. The company informs TorrentFreak that further legal action is on the cards.

“There have been several recent court rulings related to the ban on the sale of Roku devices in Mexico. In fact, a Federal court in Mexico City has already determined that the ban was improper; however, the ban remains in place,” says Roku spokesperson Tricia Misfud.

“While Roku’s devices have always been and remain legal to use in Mexico, the current ban harms consumers, the retail sector and the industry. We will vigorously pursue further legal actions with the aim of restoring sales of Roku devices in Mexico.”

Despite a nationwide sales ban, people who already have a Roku in their possession remain unaffected by recent developments. Since the use of Roku devices in Mexico and elsewhere is completely legal, current users will still receive regular software updates.

In associated news, Mexico’s Telecommunications Law Institute (IDET) reports that the Mexican Institute of Industrial Property (IMPI) has been blocking URLs used to distribute unauthorized content and apps.

While that will undoubtedly prove unpopular with pirates, one hopes that its execution is somewhat more precise than the wholesale banning of the entire Roku platform.

Source: TF, for the latest info on copyright, file-sharing, torrent sites and more. We also have VPN reviews, discounts, offers and coupons.

Logic Supply launches tiny, fanless, Ubuntu-powered PCs

Industrial PC maker Logic Supply has been offering small fanless computers for years, but the company says its new CL200 series PCs are its smallest to date. Powered by an Intel Celeron N3350 dual-core processor, the little computer measures just 4.6″ …

Industrial PC maker Logic Supply has been offering small fanless computers for years, but the company says its new CL200 series PCs are its smallest to date. Powered by an Intel Celeron N3350 dual-core processor, the little computer measures just 4.6″ x 3.3″ x 1.3″, making it smaller than a typical Intel NUC computer. Logic […]

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