Potent Nocebo: The more expensive a harmless cream, the more pain it inflicts

The flip-side of placebo effect is more dangerous side effects—and the pain is real.

Enlarge / Ow. (credit: Getty Images | Media for Medical)

The mind is a powerful medicine. Given an ineffective treatment, patients can experience real health improvements by simply believing that the treatment works—the placebo effect. But this blissful delusion has a dark side: when a harmless placebo becomes effective, it becomes harmful, too, causing side-effects seen in actual therapies.

In a new study exploring this mysterious “nocebo effect,” researchers pinpoint regions of the brain that seem to be behind phantom injuries. They also assess factors—framing and price—that can increase the potency of the effect. These may be critical to designing and assessing clinical practices and trial results, they argue.

Specifically, researchers gave patients a sham anti-itch cream for eczema (atopic dermatitis) and told them it increases sensitivity to pain as a side effect—which is a side effect of real medicines, but the phony cream shouldn’t have any side effects. Nevertheless, patients not only reported more pain, but the amount of pain they reported depended on the cream’s price and packaging. The cream caused more pain in patients when they were told it had a hefty price tag and came in a brand-name-looking box, compared with when they thought it was a cheap cream that came in a generic-looking box. The researchers, led by neuroscientist Alexandra Tinnermann of University Medical Center Hamburg-Eppendorf, published the results recently in Science.

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Dealmaster: Get Columbus Day deals on Sonos speakers and Dell laptops

Plus deals for Lenovo ThinkPads, Amazon Kindles, and Sony’s PlayStation 4 Pro.

Greetings, Arsians! Courtesy of our friends at TechBargains, we have another round of deals to share. Regardless of whether you look at Columbus Day as a worthy tradition, a whitewashing of history, or just a day off from work, there's no denying that it's typically a good time to grab some discounts. Today's edition is no different, as we're serving up savings on Dell and Lenovo laptops, Sonos speakers, Amazon gadgets, and more.

You can see the full list of deals below.

Note: Ars Technica may earn compensation for sales from links on this post through affiliate programs.

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ZTE Axon M dual-screen smartphone hits the FCC

It’s official: ZTE is developing a smartphone called the Axon M, and it sure looks like it’ll probably be the dual-display that we’ve been expecting (thanks to a series of leaks). A device called the ZTE Axon M showed up at the FCC we…

It’s official: ZTE is developing a smartphone called the Axon M, and it sure looks like it’ll probably be the dual-display that we’ve been expecting (thanks to a series of leaks). A device called the ZTE Axon M showed up at the FCC website today, and while the documents don’t include photos or detailed specs, […]

ZTE Axon M dual-screen smartphone hits the FCC is a post from: Liliputing

Windows Phone is now officially dead: A sad tale of what might have been

Tweets over the weekend confirm what we long suspected.

During the weekend, Microsoft's Joe Belfiore tweeted confirmation of something that has been suspected for many months: Microsoft is no longer developing new features or new hardware for Windows Mobile. Existing supported phones will receive bug fixes and security updates, but the platform is essentially now in maintenance mode.

Microsoft's difficulties in the mobile market are no secret, but for a time the company looked as if it was keeping Windows Mobile as a going concern regardless. Through 2016, Microsoft produced new builds for the Windows Insider program and added new features to Windows Mobile. At around the time of release of the Windows 10 Creators Update in April this year, that development largely ground to a halt. Windows Mobile, which already lacked certain features that were delivered to Windows on the PC, had its development forked. PC Windows development continued on the "Redstone 3" branch (which will culminate in the release of the Fall Creators Update later this month); Windows Mobile languished on a branch named "feature2."

But in spite of this, until Belfiore's tweets at the weekend, Microsoft never actually said what its plans for Windows Mobile were or how it would be developed going forward.

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Loot boxes in video games will soon get a review flag from OpenCritic

“We’re going to take a stand” following poisonous boxes in new LOTR, Star Wars games.

Enlarge (credit: OpenCritic)

In the week since I ranted about the increasingly poisonous practice of loot boxes appearing in retail-priced video games, more big-ticket titles have shown up to the loot box party. Apparently, we're not the only folks fed up with the trend, which combines slot-machine psychology with unclear real-money economies in games. On Monday, the review-aggregation site OpenCritic announced the first major game-review initiative to combat the practice.

"We're going to take a stand against loot boxes," the site announced on its Twitter feed. "We're looking into ways to add business model information to OpenCritic."

OpenCritic says it's currently testing a number of flags that can be applied to a given game's review page. The simplest ones would clarify whether a game has a "loot box" system that randomizes your progress in a game, as opposed to an experience-driven or store-driven system that lets players freely choose any changes or upgrades. OpenCritic would also judge a loot box system's "buying power" to clarify whether a game's randomly generated loot boxes contain anything beyond a "cosmetic" tweak.

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It sure looks like Waymo is getting ready to launch in Phoenix

Waymo will run ads in Phoenix touting the benefits of self-driving technology.

Enlarge / One of the earliest families in Waymo's public trial in Phoenix poses with a Waymo minivan. (credit: Waymo)

Waymo, Google's self-driving car company, is laying the political groundwork to launch a truly driverless car service. On Monday, the company announced a new partnership with several non-profit organizations.

Called "Let's Talk Self-Driving," the partnership aims to persuade Americans—and especially people in the Greater Phoenix area—of the benefits of self-driving cars. "We're starting this campaign with a series of digital, outdoor, and radio advertising in Arizona," Waymo CEO John Krafcik says in a blog post announcing the campaign.

Companies run ads promoting their products all the time, so on its own this isn't very surprising. But two things stand out about the Waymo campaign.

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New bill would end Native American “sovereign immunity” for patents

Sen. McCaskill: “One of the most brazen and absurd loopholes I’ve ever seen.”

Enlarge / US Sen. Claire McCaskill (D-Mo.) at a hearing earlier this year. (credit: Mark Wilson/Getty Images)

Allergan's move to stop its patents from being reviewed by handing them off to a Native American tribe is winning support from few people outside the drug company. Now one lawmaker is seeking to ban it.

Sen. Claire McCaskill (D-Mo.) has introduced a bill (PDF) that would head off Allergan’s strategy without waiting to see whether the judges at the Patent Trial and Appeals Board will even approve it.

“This is one of the most brazen and absurd loopholes I’ve ever seen, and it should be illegal,” McCaskill said last week in a statement to a pharmaceutical lobby group.

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New Pacific Rim Uprising trailer debuts at NY Comic Con

John Boyega stars in a sequel about a new generation of Jaeger pilots.

New York Comic Con brought a deluge of geeky movie trailers this weekend. Among them is Pacific Rim Uprising, sequel to the kaiju-inspired monster disaster movie Pacific Rim. In the first film, pilots inhabited giant robots that fought off massive inter-dimensional monsters. Uprising looks like more of the same, and that's nothing to complain about.

Uprising takes place 10 years after the first film. After the successful but costly defeat of the monsters, that giant robot program is still going. The trailer seems to suggest that the focus is on a "new generation" of young pilots who are operating several new types of robots to defeat more invaders—including at least one with some cool-looking lightning swords. In general, the battles look more martial arts-inspired than those in the first film. Star Wars: The Force Awakens' John Boyega leads the cast, playing the son of Idris Elba's character from the first film.

Pacific Rim didn't recoup its budget on the US box office alone, but it reportedly did very well in China. It's fitting that Pacific Rim Uprising was largely shot in China, then. Pacific Rim was directed by Guillermo del Toro, but the sequel has a new director—Steven S. DeKnight, a writer, producer, and director known for his work on TV shows like DaredevilSmallville, Spartacus, and various Joss Whedon projects like Buffy the Vampire SlayerAngel, and Dollhouse. Uprising is his feature film directing debut, but his pedigree is enough to keep fans from being nervous.

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Roku Shows FBI Warning to Pirate Channel Users

The popular media player Roku is flashing an FBI anti-piracy warning to users of “pirate” channels, including XTV. After been shown the FBI’s well known anti-piracy seal, users are informed that unauthorized copying is punishable under federal law and that the associated channel was removed.

Source: TF, for the latest info on copyright, file-sharing, torrent sites and ANONYMOUS VPN services.

In recent years it has become much easier to stream movies and TV-shows over the Internet.

Legal services such as Netflix and HBO are flourishing, but at the same time millions of people are streaming from unauthorized sources, often paired with perfectly legal streaming platforms and devices.

Hollywood insiders have dubbed this trend “Piracy 3.0” and are actively working with stakeholders to address the threat. One of the companies rightsholders are working with is Roku, known for its easy-to-use media players.

Earlier this year a Mexican court ordered retailers to take the Roku media player off the shelves. This legal battle is still ongoing, but it was a clear signal to the company, which now has its own anti-piracy team.

Several third-party “private” channels have been removed from the player in recent weeks as they violate Roku’s terms and conditions. These include the hugely popular streaming channel XTV, which offered access to infringing content.

After its removal, XTV briefly returned as XTV 2, but that didn’t last for long. The infringing channel was soon removed again, this time showing the FBI’s anti-piracy seal followed by a rather ominous message.

“FBI Anti-Piracy Warning: Unauthorized copying is punishable under federal law,” it reads. “Roku has removed this unauthorized service due to repeated claims of copyright infringement.”

FBI Warning (via Cordcuttersnews)

The unusual warning was picked up by Cordcuttersnews and states that Roku itself removed the channel.

To some it may seem that the FBI is cracking down on Roku channels, but this is not the case. The anti-piracy seal and associated warning are often used in cases where the organization is not actively involved, to add extra weight. The FBI supports this, as long as certain standards are met.

A Roku spokesperson confirmed to TorrentFreak that they’re using it on their own accord here.

“We want to send a clear message to Roku customers and to publishers that any publication of pirated content on our platform is a violation of law and our platform rules,” the company says.

“We have recently expanded the messaging that we display to customers that install non-certified channels to alert them to the associated risks, and we display the FBI’s publicly available warning when we remove channels for copyright violations.”

The strong language shows that Roku is taking its efforts to crack down on infringing channels very seriously. A few weeks ago the company started to warn users that pirate channels may be removed without prior notice.

Source: TF, for the latest info on copyright, file-sharing, torrent sites and ANONYMOUS VPN services.

Advertised broadband speeds should actually be realistic, UK tells ISPs

ISPs would have 30 days to improve speeds or risk losing customers.

Enlarge / BT Openreach van and a coil of yellow broadband fibre cable awaiting installation in February 2017 in London, England. (credit: Getty Images | Richard Baker)

The United Kingdom's telecom regulator, Ofcom, wants to strengthen an industry code that lets Internet customers exit contracts without penalty when broadband providers fall short of their advertised speeds.

Ofcom's proposed changes would also improve the accuracy of speed information provided to customers before they sign up for broadband. Ofcom intends to add the new guidelines to its existing codes of practice for residential and business broadband speeds, which already "commit Internet companies who have signed up to them to give customers an estimated range of speeds they are likely to receive, as well as the right to exit their contracts penalty-free if their speed falls below a minimum level."

The regulator described proposed additions to the code on Friday, saying that its plan is to:

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