Researchers cautiously optimistic about new brain-clearing Alzheimer’s drug

Drug breaks down brain plaques—but it’s not the first with promising early data.

Enlarge (credit: Getty | Brian B. Bettencourt )

A new Alzheimer’s disease drug may be able to clear away goopy piles of toxic proteins in patients' brains—hallmarks of the progressive disorder. The drug is an antibody directed at the proteins themselves, and the promising results come from a small, phase I safety trial.

To date, no other drug has shown this much brain-clearing power. If the results hold up in larger trials, the drug has the potential to prevent or even reverse the progression of the disease. But researchers caution that excitement should be tempered; it's far too early to decipher the drug’s true potential. Similar antibody-based drugs have given promising results in early trials but went on to fail spectacularly in larger studies—in some cases even causing death.

“I am cautiously optimistic about this treatment, but trying not to get too excited,” Tara Spires-Jones, interim director of the Centre for Cognitive and Neural Systems at the University of Edinburgh, said in a media statement. “This was a small phase I study with 20-30 people in each treatment group. We will have to wait and see whether the promising results reported here are repeated in the larger phase III trials of this drug that are currently underway worldwide.”

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Apple is cleaning up the app store, removing outdated apps starting September 7th

Apple is cleaning up the app store, removing outdated apps starting September 7th

It’s been more than 8 years since Apple launched the App Store. Developers have uploaded more than 2 million apps since 2008… and some of them are woefully out of date.

So Apple has announced plans to start cleaning up.

Starting September 7th, the company plans to review and remove apps that are outdated, don’t work properly anymore, or don’t comply with current guidelines (even if they were fine when they were originally submitted to the App Store).

Continue reading Apple is cleaning up the app store, removing outdated apps starting September 7th at Liliputing.

Apple is cleaning up the app store, removing outdated apps starting September 7th

It’s been more than 8 years since Apple launched the App Store. Developers have uploaded more than 2 million apps since 2008… and some of them are woefully out of date.

So Apple has announced plans to start cleaning up.

Starting September 7th, the company plans to review and remove apps that are outdated, don’t work properly anymore, or don’t comply with current guidelines (even if they were fine when they were originally submitted to the App Store).

Continue reading Apple is cleaning up the app store, removing outdated apps starting September 7th at Liliputing.

Apple could bring home billions in taxes if US passes a tax holiday

Law prof: “For the most part, companies like Apple don’t need to repatriate money.”

Enlarge (credit: frankieleon)

In an interview with Irish public broadcaster RTÉ, Apple CEO Tim Cook said Thursday that the company planned on bringing billions of dollars held overseas back to the United States to be subject to American taxes.

"We provisioned several billion dollars for the US for payment as soon as we repatriate it, and right now I would forecast that repatriation to occur next year," Cook said.

The interview came two days after the European Commission ordered Ireland to collect €13 billion (£11.1 billion/$14.5 billion) in back taxes from Apple, after the company benefitted from years of a sweetheart deal and dubious, but legal, tax shenanigans.

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Apple to begin removing old, unmaintained apps from the App Store

Move is meant to improve compatibility and cut down on abandonware.

Enlarge / Apple is cleaning its (app) house ahead of this fall's big releases.

Apple is making a few small tweaks to its App Store Review Guidelines for developers ahead of the release of iOS 10 and macOS Sierra this fall. The changes, which Apple is currently telling registered developers about via e-mail, are meant to cut dead wood out of the App Store and to make it easier for users to find better apps. These are the latest in a series of App Store changes implemented since Apple worldwide marketing SVP Phil Schiller was given the reins back in December of 2015.

The biggest change is that Apple will begin to remove older, outdated apps from the App Store that no longer follow current review guidelines or that haven't been updated to support new APIs or features. Removing old apps will also cut down on the number of apps that haven't been updated for compatibility with newer iOS versions or iDevices.

Apple isn't saying exactly what criteria it will use to remove apps, just that it is "implementing an ongoing process of evaluating apps for these issues, notifying their developers, and removing problematic and abandoned apps." People who have already downloaded these apps will still be able to download them, developers will be given 30 days to issue an update before their app is removed, and if their apps are removed they will still be associated with that developer's account and other developers won't be able to use the names for other apps.

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Qualcom launches Snapdragon 820 reference designs for VR headsets, TV boxes

Qualcom launches Snapdragon 820 reference designs for VR headsets, TV boxes

There are a bunch of high-end smartphones powered by Qualcomm’s Snapdragon 820 processor, but the chip maker thinks the CPU can also be used in other types of hardware.

So Qualcomm is introducing new reference designs for products that utilize the Snapdragon 820 chipset, including a Snapdragon VR820 VR headset and a 4K Ultra HD media box reference platform.

Snapdragon VR820

Technically any phone with a Snapdragon 820 chip can also be used as a virtual reality headset: just stuff it into a Google Cardboard or DayDream-style headset (or Samsung Galaxy Gear, if you have a supported model).

Continue reading Qualcom launches Snapdragon 820 reference designs for VR headsets, TV boxes at Liliputing.

Qualcom launches Snapdragon 820 reference designs for VR headsets, TV boxes

There are a bunch of high-end smartphones powered by Qualcomm’s Snapdragon 820 processor, but the chip maker thinks the CPU can also be used in other types of hardware.

So Qualcomm is introducing new reference designs for products that utilize the Snapdragon 820 chipset, including a Snapdragon VR820 VR headset and a 4K Ultra HD media box reference platform.

Snapdragon VR820

Technically any phone with a Snapdragon 820 chip can also be used as a virtual reality headset: just stuff it into a Google Cardboard or DayDream-style headset (or Samsung Galaxy Gear, if you have a supported model).

Continue reading Qualcom launches Snapdragon 820 reference designs for VR headsets, TV boxes at Liliputing.

Hanjin bankruptcy could mean price spikes for TVs, cars, other large products

Tuesday filing has driven shipping rates up 55 percent for affected routes.

Enlarge / Prepare to see less activity on Hanjin ships thanks to a bankruptcy filing this week. (credit: Josh Hallett)

TV manufacturers have moved on to another set of standards, hoping to convince us to pay up for new sets, but adoption of standards such as 4K resolution and "high dynamic range" (HDR) displays may very well live and die by finding the right price point in stores. That won't be easier for Korean monitor makers in the coming months, however, thanks to the Tuesday bankruptcy filing by major South Korean shipping company Hanjin.

South Korean electronics company LG made a Thursday announcement confirming that it would immediately cancel all overseas shipments with Hanjin—primarily because the company's ships, crates, and other major shipping assets have been seized at various ports across the world and are not being allowed entry at other ports out of fears that Hanjin will not be able to pay required fees. Other manufacturers of major mechanical and large-electronic products, including Samsung, have also confirmed feeling the Hanjin-related pinch. As a result, shipping rates are jumping drastically.

As Reuters reports, shipping rates have jumped "about 55 percent" on the routes normally trafficked by Hanjin ships—and companies like Hyundai, which operates its own shipping business, are enjoying the spoils. In the meantime, slowed and stranded shipments could have an immediate impact on product prices for big-ticket electronics, especially as retailers ramp up for the American holiday shopping season. Air freight is often relied upon more heavily for smaller-sized electronics like smartphones, so Hanjin's woes shouldn't impact prices on those products. But whether due to rarity or higher shipping prices, things probably won't get any cheaper for any larger products made by South Korean companies this fall and winter.

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Easy Cake Cutting Knife

When cutting cake, the most unpleasant experience is when trying to pull out the first piece of cake without messing with the other one. I’m not a gently guy who can precisely cut and pull it out in a perfect piece. So using the usual plastic cake knife is not for me. If you are […]

When cutting cake, the most unpleasant experience is when trying to pull out the first piece of cake without messing with the other one. I’m not a gently guy who can precisely cut and pull it out in a perfect piece. So using the usual plastic cake knife is not for me. If you are […]

Music Group Protests ISPs Move for a Declaratory Ruling on Piracy Liability

Music rights group BMG says that Internet providers RCN and Windstream should not be allowed to obtain a declaratory judgment on their potential liability for pirating subscribers. According to BMG, the providers are improperly trying immunize themselves, hiding behind the DMCA’s safe harbor.

Source: TF, for the latest info on copyright, file-sharing, torrent sites and ANONYMOUS VPN services.

bmgrightsCan an Internet provider be held liable for subscribers who share pirated files? Yes, a Virginia federal jury ruled late last year.

This verdict caused shockwaves in the ISP industry when several companies suddenly realized that they could become the next target.

Internet provider RCN is among the companies that are gravely concerned. With 400,000 subscribers nationwide, it is one of the larger Internet providers in the United States, and as such it regularly receives takedown notices targeting it its subscribers.

Many of these notices come from BMG and its anti-piracy partner Rightscorp, which accuse RCN of being liable for the actions of its customers.

RCN was not pleased with these allegations and took legal action a few weeks ago. The Internet provider filed a lawsuit against music rights group BMG at a New York federal court, seeking declaratory judgment on the matter.

“The central question for this Court’s determination is whether an Internet service provider should be held liable for copyright infringement simply because it provides Internet connectivity to its customers,” RCN wrote.

The Internet provider argued that it is not liable for the infringements of its subscribers because it is merely passing on traffic, which allows the company protection under the DMCA’s safe harbor provision.

RCN is not the only ISP to have taken action. Their complaint was swiftly followed by a similar case from Windstream, which relies on many of the same arguments.

BMG is not happy with these developments and has started to push back in court. In both cases, the music rights group has now asked the court for leave to file a motion to dismiss the complaints.

According to BMG, there is no concrete dispute or threat of an actual lawsuit on their part. Instead, they accuse the ISPs of trying to get broad immunity without going into specifics, such as their repeat infringer policies.

“RCN appears to seek to resolve only its liability for past instances of infringement, but declaratory judgment actions are not the proper vehicle by which to do so,” BMG’s lawyers write in the RCN case.

“Conversely, to the extent RCN seeks to immunize itself against liability for future infringement, there is no factual record on which to make such a decision. A Court cannot offer a declaratory judgment immunizing purely hypothetical future conduct from secondary liability for copyright infringement.”

As the Cox case has shown, the ISPs’ actions and policies play a crucial role in determining liability. BMG accuses RCN, and in a similar filing Windstream, of trying to escape this responsibility.

“In sum, RCN seeks a broad ruling that it does not infringe BMG’s copyrights at any time or anywhere, regardless of the factual circumstances or its actual knowledge of copyright infringement by RCN subscribers. That is not the proper subject of a declaratory judgment action and does not state a legally valid claim under the DMCA or the Copyright Act.”

RCN does not agree with the music group’s characterization of its request. In a reply, the ISP highlights that it received millions of infringement notices from BMG over the past years, in which it demanded compensation from RCN.

“They present a substantial, real, and immediate controversy in that BMG has accused RCN of specific and continuing instances of copyright infringement and has provided a definitive measure of the damages for which RCN is allegedly liable,” RCN writes in its reply.

“As a result, there is nothing abstract or hypothetical about the relief RCN is seeking in this declaratory action. RCN properly seeks a declaration that BMG’s allegations lack merit and that RCN is not liable for purported copyright infringement occurring through its network.”

As such, RCN asks the court not to allow the motion to dismiss to be filed.

Windstream has yet to reply to the allegations, but it’s expected that they will follow the same course as their colleague Internet provider, as they’ve previously done.

Source: TF, for the latest info on copyright, file-sharing, torrent sites and ANONYMOUS VPN services.

Deals of the Day (9-01-2016)

Deals of the Day (9-01-2016)

Newegg is selling a tablet with a 10.6 inch full HD display, Windows 10 Pro software, a detachable keyboard, and a Wacom digitizer and pen for $360.

It has 4GB of RAM, 64GB of storage, and an Intel Core M Broadwell processor. Sounds like a lot of bang for not a lot of bucks… but there’s a catch: I’ve never heard of the company behind this 2-in-1 tablet.

If that doesn’t scare you off, the Mytrix Complex tablet doesn’t seem to have much of a warranty, but you can return it within 30 days (athough there’s a 15% restocking fee).

Continue reading Deals of the Day (9-01-2016) at Liliputing.

Deals of the Day (9-01-2016)

Newegg is selling a tablet with a 10.6 inch full HD display, Windows 10 Pro software, a detachable keyboard, and a Wacom digitizer and pen for $360.

It has 4GB of RAM, 64GB of storage, and an Intel Core M Broadwell processor. Sounds like a lot of bang for not a lot of bucks… but there’s a catch: I’ve never heard of the company behind this 2-in-1 tablet.

If that doesn’t scare you off, the Mytrix Complex tablet doesn’t seem to have much of a warranty, but you can return it within 30 days (athough there’s a 15% restocking fee).

Continue reading Deals of the Day (9-01-2016) at Liliputing.

AT&T’s throttling victory may hinder FTC’s power to protect consumers

Ruling raises questions about FTC ability to regulate Google, Verizon.

Enlarge (credit: Getty Images | Andy Cross)

AT&T's court victory over the Federal Trade Commission (FTC) this week had the immediate effect of helping the carrier avoid punishment for throttling the Internet connections of customers with unlimited data plans. The judges' decision could also have a long-term impact on the FTC's ability to enforce consumer protection laws.

The FTC's charter from Congress already prohibited the FTC from regulating common carriers, a designation that the Federal Communications Commission (FCC) has long applied to AT&T and other phone companies. But the FTC thought it could police non-common carrier activities regardless of whether another part of a company's business falls under the FCC's common carrier designation.

When the FTC sued AT&T in October 2014, the company was a common carrier for phone service but not for Internet access. The FTC argued that it could regulate AT&T's non-common carrier mobile data business, but AT&T argued that it was entirely exempt from FTC jurisdiction because it was a common carrier for voice service.

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