Stem cell organization to scientists: Enough with the hype!

Giving a misleading impression of the state of research is not a good thing.

As we discussed on Tuesday, a lot of the problems with the public's view of current research originate long before journalists get involved. Scientists and the institutions that support the research often portray preliminary work as more definitive than it is, or push the findings as supporting ideas that are, at best, premature. So it's nice to see that one organization of scientists is pushing back against that.

The organization is the International Society for Stem Cell Research (ISSCR), which has just released an updated set of guidelines for stem cell researchers. The majority of the text is devoted to research ethics and best practices, and it covers topics like patient data. But the new version includes a section devoted to communications, and it nicely summarizes some of the problems that the field has faced since its inception:

Popular coverage and reporting in the medical literature are frequentlyfar from ideal. Potential benefits are sometimes exaggerated and the challenges to clinical application and risks are often understated. Inaccurate or incomplete representations of this sort can have tangible impacts on the expectations of the general public, patient communities, physicians, and on the setting of health and science policies. Inaccurate or incomplete representations can also be exploited by companies and individuals marketing stem cells for unproven clinical uses.

How to combat this? The ISSCR lays the responsibility on the shoulders of researchers and the press officers who work with them, advising them in a variety of ways to cut out the hype. "Communications about ongoing studies should explain that clinical efficacy is not established," the guidelines state, "and that the results may reveal the intervention to be ineffective or, in some cases, harmful." Clinical trials that focus on establishing safety should not be referred to as treatments. And researchers shouldn't be in the business of predicting the future of uncertain processes like the movement of a treatment through clinical trials—any forward-looking statements "must be accurate, circumspect and restrained."

The guidelines warn against what's become a common practice in clinical studies: when the focus of the work produces a negative result, the researchers go searching for any measure that turns up positive and shift the focus to that. Researchers are advised to always report the intended measures, even if they fail.

Finally, researchers are advised that their work doesn't end when the press coverage starts. If any public representations of research are inaccurate or misleading—be it a press release or ensuing coverage—it's the researchers' job to get them corrected.

Will this cause all stem cell researchers to immediately take their responsibilities as public communicators seriously? Certainly not. But having clear and strong standards—which these certainly appear to be—provides a strong lever to begin to shift behavior. It's much easier to convince someone that they're being irresponsible when an organization of their peers has already clearly described why those actions are irresponsible.

EPA issues rules to cut methane, volatiles from new oil and gas sites

Asks for data on existing hardware to prep rules for that, too.

Today, the US Environmental Protection Agency announced that it had completed rules that will regulate methane and other emissions from new natural gas and oil drilling sites. The rules, which have already received extensive public and industry comment, are focused on methane due to its potency as a greenhouse gas, but they'll also limit emissions of toxic chemicals and pollutants that contribute to ground-level ozone. In making the announcement, the EPA also issued a call for data regarding existing hardware; it intends to eventually regulate the emissions from that, as well.

The new rules cover any new or updated hardware for oil and natural gas wells, as well as sites that collect, process, and compress natural gas for distribution. Formulated under the Clean Air Act, they had already gone extensive public comment. In response, the EPA tightened a few cases; low production wells will now have to be monitored, and the frequency of monitoring at compressor stations was increased.

The rule is focused on methane emissions, and the EPA estimates that it will cut the greenhouse equivalent of 11 million metric tons of carbon dioxide (out of the US' roughly 5.3 billion). But as a side benefit, release of various organic toxins, including benzene, toluene, and xylene, will also be cut, as will emissions of ozone-forming chemicals. The Agency hasn't quantified the value of the ensuing health benefits, but it figures the climate benefits by 2025 ($690 million) will significantly outweigh the implementation costs ($530 million).

The limited emissions cuts are at least in part due to the fact that the rules are focused on new and upgraded hardware; they don't touch existing equipment. But that should change. The Obama administration has set a goal of reducing methane emissions from the oil and natural gas industries by 40 percent in 2025. And in announcing the new rules, the EPA stated, "EPA is also starting the process to control emissions from existing sources by issuing for public comment an Information Collection Request that requires companies to provide the information that will be necessary for EPA to reduce methane emissions from existing oil and gas sources."

Tightly packed four-planet system formed by planet migration

Migrating orbits may be a normal part of forming exosolar systems.

Artist's conception of a hot Neptune orbiting close to its host star. Kepler-223 has four such planets, all with orbital periods of less than 20 days. By contrast, Mercury's orbit takes 88 days. (credit: NASA/JPL-Caltech)

How did our solar system reach its current configuration? One of the leading candidates to explain things like the sparseness of the Asteroid Belt and the small size of Mars is the grand tack, in which Jupiter originally migrated inward toward the Sun until its interactions with Saturn pulled them both back outward.

The idea that giant planets may go for a wander around their star's orbital neighborhood has picked up some support from many of the exosolar systems we've discovered. We've spotted tightly packed systems of large planets when there probably wasn't enough material in the region to form all of them, suggesting that they formed somewhere else and then migrated into place.

But this idea raises some questions. What stops the planets from their wanderings, keeps them from smashing into each other, and prevents them from falling into their host star? A phenomenon known as orbital resonance may be the answer, and researchers argue that it explains the presence of four exoplanets all with orbits of less than 20 days.

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John Oliver’s rant about science reporting should be taken seriously

Business decisions, institutional pressures, and scientists themselves share blame.

Over the course of the spring, I had the chance to talk about science journalism at a number of universities. (Thanks to the folks at Washington University in St. Louis and the University of Illinois in Chicago for inviting me.) It took about 45 minutes for me to discuss the issues involved and provide a number of examples of things gone badly wrong.

On Sunday, John Oliver managed to cover the same ground and more, and he did it with a lot more flair and humor—all in under 20 minutes. If you have the time, it's well worth a watch.

John Oliver talks about science in the media.

On Monday, all these science journalism problems were driven home yet again. The University of Gothenburg issued a press release suggesting that hunger influences our decision-making processes. This finding shouldn't be a huge surprise; anything that distracts us seems to influence our ability to make decisions. But the release itself is a perfect example of many of the problems Oliver pointed out.

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Weasel’s suicide delays but does not stop our biggest particle collider

Plans call for six times the data as last year.

(credit: LHCb)

After more than a month of checking out the equipment, the Large Hadron Collider is set to return to the frontiers of particle physics. This will be the second run at higher energies after a few years at lower energy and a couple years of upgrades. The plan for this year is to increase the frequency of high-energy collisions in order to get a better view of the Higgs boson and pursue the search for new particles.

After suffering a catastrophic failure early in its history, the LHC was run for several years at energies that created collisions at seven or eight Tera-electronVolts. This was followed by an extended shutdown that upgraded hardware and fixed the defects that caused the earlier failure. Last year's physics run was the fist at 13TeV, and the collider's operators were relatively cautious as they learned how to control the machine at these higher energies.

The new energies provide two major advantages. Since new particles are created by converting energy to matter, the higher the energy, the heavier the particles you can produce. And some analyses have been finding hints that there might be a new particle in the neighborhood of 750 Giga-electronVolts—nearly 800 times the mass of the protons that were smashed to create it.

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US carbon emissions drop, now 12% below 2005 levels

Transition from coal to natural gas gets most of the credit.

(credit: US EIA)

US carbon emissions were down slightly in 2015, continuing a period in which economic growth has been accompanied by relatively flat emissions. Compared to 2005, however, the current numbers represent a 12 percent drop. The Energy Information Agency (EIA) indicates this has largely been caused by the transition from coal to natural gas.

US carbon emissions saw a significant drop during the 2008-2009 economic crisis, driven largely by falling economic activity. As the economy began to rebound in 2010, so did carbon emissions. But succeeding years have seen a series of relatively minor ups and downs—the current numbers represent a drop of about two percent compared to 2014. Notably, the emissions are also below those at the height of the economic crisis in 2009.

That's rather significant, as economic growth has been consistently in the neighborhood of two percent since 2010. This provides a strong indication that, for the moment at least, the US has decoupled economic growth from carbon emissions. Overall, the economy is up about 15 percent since 2005 when inflation is taken into account.

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Understanding ketamine to make a fast-acting, safe antidepressant

The body converts the anesthetic ketamine into an effective treatment in mice.

(credit: Wikimedia Commons)

Clinical depression is a devastating disease that is made worse by the lack of effective treatment. Several drugs can treat the disease, but they take months to become effective, often causes side effects, and only work in a subset of the patient population. Treatment often begins with an extended period of trial and error, sometimes taking over a year.

Ketamine provides a shortcut. The drug can often lift symptoms of depression in under 24 hours, and the effects persist for roughly a week after a single administration. So why isn't everybody using it?

Well, ketamine comes with some pretty dramatic side effects. At high concentrations, it creates a combination of sedation and pain relief, while blocking memory use, making it an effective anesthetic. At lower concentrations, it produces a dissociative state, which has led to the drug being used recreationally. In either case, coming down from these states tends to produce disorientation and sometimes more severe problems. So, ketamine is not quite ready for widespread use.

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Martian water blasts away sand, may craft features as it boils

Melting ice at Martian pressures gives sand some serious pop.

The complex pattern left behind by liquid water flowing through sand under Martian atmospheric pressures. (credit: M. Massé)

We now know that there is liquid water on the surface of Mars. Streaks of dark material flow down crater walls, appearing and disappearing with the seasons. Imaging from orbit has confirmed that these features contain hydrated salts, leading researchers to conclude that the water took the form of a salty brine, which would prevent it from immediately evaporating into Mars' cold, thin atmosphere.

But a new paper released today argues that we might want to rethink the role of brine. The international team behind it tested what would happen if pure water were flowing through sand under Mars-like conditions. Some of the water boiled off quickly, but it managed to spread a bit further than expected and produced features similar to some that have been imaged from orbit.

There are a number of challenges with figuring out what's happening on Mars. The first is that we've got no hardware anywhere near where the watery features form; all our direct exploration has to take place from orbit. Another challenge is that we don't know the nature of the water. At Martian pressures, pure water could boil at temperatures reached in the daytime and freeze at night, while salts could keep it liquid at the prevalent temperatures.

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Researchers evolve new toxin to target agricultural pests

Amazing biotechnology creates a backup to current insect-killing GMO crops.

The dread cabbage looper. (credit: Peggy Greb/USDA)

Bacillus thuringiensis (Bt) crops have been one of the most successful applications of genetic engineering in agriculture. The crops carry a gene that encodes a bacterial protein that kills insects that ingest it. While it's possible to spray crops with the Bt toxin instead, farms that rely on Bt GMO crops are more profitable, have higher productivity, and use less pesticides.

Unfortunately, evolution isn't sitting still, and Bt-resistant insects are beginning to become a problem. While scientists are developing new crops with other Bt genes and farmers can adopt agricultural practices that limit the risk of resistance, some researchers decided to short-circuit the whole process. In a new paper, they figured out how to evolve a completely new Bt toxin in a virus that infects bacteria and showed that it was effective in killing insects.

The basics of Bt

The researchers' work highlights the importance of basic, fundamental research—while a handful of the research team worked at Monsanto, two-thirds came from various academic institutions. And the work relies on some basic information that's not essential to using Bt in GMOs.

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Hubble spots a Makemake moon

Body will be key to understanding Makemake’s composition, history.

Enlarge / The arrow points to the very faint moon near Makemake. (credit: NASA, ESA, and A. Parker)

Today, NASA announced that images it has been sitting on for a year show a moon orbiting a dwarf planet in the Kuiper belt. The moon, formally known as S/2015 (136472) and going informally as MK 2, is in orbit around Makemake, a dwarf planet two-thirds the size of Pluto that spends most of its time more than 40 Astronomical Units away from the Sun (1 AU is the typical Earth-Sun distance).

MK 2 is more than 1,300 times fainter than the planet it orbits, largely because it has a very dark surface compared to Makemake's icy white color. It also appears to orbit within the plane of the Solar System, which means it's indistinguishable from Makemake for much of its orbit—Hubble managed to catch it when it was more than 20,000km from the dwarf planet. Estimates are that MK 2 is about 160km across compared to Makemake's 1,400km.

Early observations show that the orbit takes at least 12 days, and the shape of the orbit is roughly circular. This data suggests that MK 2 formed from debris liberated from Makemake by an impact; passing objects that are captured by planets typically have eccentric orbits. Detailed observations of MK 2's orbit will allow us to determine the density of Makemake, which will then tell us something about its composition, so NASA will continue observing the new body.

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