Month: June 2016

MS brain lesion as seen on an MRI. (credit: James Heilman, MD)

By obliterating the broken immune systems of patients with severe forms of multiple sclerosis, then sowing fresh, defect-free systems with transplanted stem cells, researchers can thwart the degenerative autoimmune disease—but it comes at a price.

In a small phase II trial of 24 MS patients, the treatment halted or reversed the disease in 70 percent of patients for three years after the transplant. Eight patients saw that improvement last for seven and a half years, researchers report in the Lancet. This means that some of those patients went from being wheelchair-bound to walking and being active again. But to reach that success, many suffered through severe side effects, such as life threatening infections and organ damage from toxicity brought on by the aggressive chemotherapy required to annihilate the body’s immune system. One patient died from complications of the treatment, which represents a four percent fatality rate.

Moreover, while the risks may be worthwhile to some patients with rapidly progressing forms of MS—a small percentage of MS patients—the researchers also caution that the trial was small and did not include a control group.

(credit: Aurich Lawson / Thinkstock)

The lawyers behind the Prenda Law "copyright trolling" enterprise have lost their key appeal and will have to pay more than $230,000 in sanctions.

The US Court of Appeals for the 9th Circuit issued a 12-page ruling [PDF] upholding the sanction order that began Prenda's downfall, issued by US District Judge Otis Wright in 2013. Today's ruling defends Wright's sanction in its entirety and doesn't give one iota of credit to the copyright troll's claims that its due process rights were violated.

Prenda Law, masterminded by two lawyers named John Steele and Paul Hansmeier, operated by filing massive lawsuits against thousands of defendants, accusing them of illegally downloading porn movies. After using the subpoena process to identify the subscribers behind the IP addresses, they'd send threatening letters about the lawsuit. Many defendants settled, either out of fear of humiliation or inability to pay for litigation. Typically, they paid around $4,000.

(credit: Warner Brothers Animation)

Like the robber barons of the Gilded Age, some of the tech billionaires of Silicon Valley are using their vast wealth to try to transform the world according to their vision(s). Bill Gates has his foundation. Elon Musk wants us to ditch the fossil-fueled car. Both Musk and Jeff Bezos want space colonies. And Google's Larry Page? He wants those flying cars we were promised.

This week Bloomberg told us that Page owns not one but two flying car startups: Zee.Aero and Kitty Hawk. Both companies appear rather media shy, but they seem to be working on small passenger aircraft that can take off and land vertically, according to reports from former employees, patent filings, and eye-witness accounts from Hollister Municipal Airport in California (where Zee.Aero is testing). The vehicles are probably using electric motors as well. "When the aircraft take off, they sound like air raid sirens," Bloomberg wrote.

Page's companies are but two among a score or more working on flying cars. There are old doyens of the field like Moller, which has been at it for more than 40 years, as well as more recent upstarts like Terrafugia and Aeromobil. It's certainly a lofty goal, but will it succeed? At the very least, it feels like some of the necessary enabling technologies are getting closer to being ready. Battery powered flight is achievable, as last year's English Channel crossing(s) demonstrated. Electric motors are smaller, lighter, and much less complex than jets, and the drone explosion serves as evidence that we can make ungainly shapes fly well even in the hands of amateurs, thanks to software.

The hammer comes down—at the workplace. (credit: Riot Games)

League of Legends creators Riot Games have never shied away from the fact that some of its players really, really suck. The company's "tribunal" answer to toxic behavior has paid big dividends in the past few years, but it hasn't zeroed out all rude players—which means Riot still had some recent data handy to connect the dots for an intriguing, workplace-related corollary.

The leading question: Does bad in-game behavior carry over to the workplace? Riot was in a position to know, since its staffers are also avid LoL players—and have apparently signed over permissions for their bosses to track their gameplay.

With help from Google's re:Work staff analytics team, Riot picked through the last 12 months of each staffer's LoL gameplay records and chat logs. The analysts found that in the case of fired employees, 25 percent of them exhibited significantly toxic in-game behavior. This wasn't a surface-level search for vulgar and hateful keywords but rather a deeper, context-specific analysis; according to re:Work, the worst behaviors included "passive aggression (snarky comments) and the use of authoritative language, sometimes using their authority as a Riot employee to intimidate or threaten others."

(credit: Getty Images | Jasper Juinen/Bloomberg)

The feud between Elon Musk company Tesla Motors and an auto blogger has sparked an indignant open letter from the company.

The feud started on Wednesday when Edward Niedermeyer posted on his blog, the Daily Kanban, that while investigating reports of suspension breakage in Tesla’s Model S and X cars he found something troubling. A poster in a Tesla Motors forum claimed the suspension in his 2013 Model S had failed. The car had 70,000 miles on it and was out of warranty, so Tesla apparently told the owner that the company would not pay for his repairs. Several days later, Tesla contacted him and offered to pay for 50 percent of the repairs if he agreed to sign a Goodwill Agreement. The agreement stipulated that the owner of the Model S would keep confidential the details of the incident and the work required to fix the car.

The Daily Kanban posted part of the agreement, which reads: